Registration Dossier
Registration Dossier
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EC number: 200-870-3 | CAS number: 75-44-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Zwart et al.
- Year:
- 1 990
- Bibliographic source:
- Phosgene, Robust Summaries, Submission to the US EPA HPV Challenge Program, July 2003 (Zwart et al., 1990).
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Phosgene
- EC Number:
- 200-870-3
- EC Name:
- Phosgene
- Cas Number:
- 75-44-5
- Molecular formula:
- CCl2O
- IUPAC Name:
- phosgene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Age: 5-6 weeks (150-170 grams/males, 130-140 grams/females)
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- >= 5 - <= 60 min
- Concentrations:
- Ranged from 26 to 856 mg/m3 (6.5 to 214 ppm)
- No. of animals per sex per dose:
- 5 males and 5 females for each species at each exposure time and
concentration - Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 306 - <= 363 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 10 min
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 334 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 10 min
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 77 - <= 92 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 30 min
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 84 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 30 min
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 45 - <= 54 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 60 min
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 49 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 60 min
Applicant's summary and conclusion
- Interpretation of results:
- very toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: Japan
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