Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Zwart et al.
Year:
1990
Bibliographic source:
Phosgene, Robust Summaries, Submission to the US EPA HPV Challenge Program, July 2003 (Zwart et al., 1990).

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
Age: 5-6 weeks (150-170 grams/males, 130-140 grams/females)

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
>= 5 - <= 60 min
Concentrations:
Ranged from 26 to 856 mg/m3 (6.5 to 214 ppm)
No. of animals per sex per dose:
5 males and 5 females for each species at each exposure time and
concentration
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LC50
Effect level:
>= 306 - <= 363 mg/m³ air
Based on:
test mat.
Exp. duration:
10 min
Sex:
male/female
Dose descriptor:
LC50
Effect level:
334 mg/m³ air
Based on:
test mat.
Exp. duration:
10 min
Sex:
male/female
Dose descriptor:
LC50
Effect level:
>= 77 - <= 92 mg/m³ air
Based on:
test mat.
Exp. duration:
30 min
Sex:
male/female
Dose descriptor:
LC50
Effect level:
84 mg/m³ air
Based on:
test mat.
Exp. duration:
30 min
Sex:
male/female
Dose descriptor:
LC50
Effect level:
>= 45 - <= 54 mg/m³ air
Based on:
test mat.
Exp. duration:
60 min
Sex:
male/female
Dose descriptor:
LC50
Effect level:
49 mg/m³ air
Based on:
test mat.
Exp. duration:
60 min

Applicant's summary and conclusion

Interpretation of results:
very toxic
Remarks:
Migrated information Criteria used for interpretation of results: Japan