Registration Dossier
Registration Dossier
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EC number: 200-870-3 | CAS number: 75-44-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Phosgene
- EC Number:
- 200-870-3
- EC Name:
- Phosgene
- Cas Number:
- 75-44-5
- Molecular formula:
- CCl2O
- IUPAC Name:
- phosgene
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 98
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium TA 100
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 rat liver
- Vehicle / solvent:
- Not specified, but unchanged phosgene was detected in the incubation medium by GC analysis only above a gaseous concentration of 10,000 ppm.
- Statistics:
- Not specified, although data points in graphs have brackets to indicate variability.
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- Phosgene is non-mutagenic under the conditions of the S. typhimurium test system, because it
reacts rapidly in the test medium. We detected unchanged phosgene in the solution only above a
gaseous concentration of 10,000 ppm. - Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
other: immeasurable
Phosgene would not be mutagenic under the conditions of liquid suspension in the Ames assay,
because this volatile gas reacts rapidly and completely with the components of the incubation
system. This does not allow measurable exposure concentrations of phosgene to be attained in
the test system. Thus, the extreme reactivity and toxicity of phosgene obviates the feasibility of
further genetic toxicity testing.
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