Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
3 (not reliable)

Data source

Reference
Reference Type:
review article or handbook
Title:
No information
Author:
Manogue and Pigford
Year:
1960
Bibliographic source:
Phosgene, Robust Summaries, Submission to the US EPA HPV Challenge Program, July 2003.

Materials and methods

Principles of method if other than guideline:
Laboratory experimental procedures. Method not known.
Study on phosgene gas dissolved in aqueous solutions
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Transformation products:
yes
Identity of transformation productsopen allclose all
No.:
#1
Reference
Reference substance name:
Unnamed
Inventory number:
InventoryMultipleMappingImpl [inventoryEntryValue=EC 204-696-9]
IUPAC name:
dioxomethane
CAS number:
124-38-9
No.:
#2
Reference
Reference substance name:
Unnamed
IUPAC name:
hydrochloric acid
Dissipation half-life of parent compound
Temp.:
25 °C
Half-life:
0 min
Type:
not specified
Details on results:
Phosgene dissolved in shore laminar jets of aqueous solutions decomposed rapidly. Rate
constants for hydrolysis to were estimated in a series of experiments in water and in sodium
nitrate and sodium hydroxide solutions at 25°C.
Estimated half-life of phosgene in water was approximately 0.026 seconds.
Phosgene hydrolyzed to carbon dioxide and hydrochloric acid in aqueous solutions.
The lack of stability of phosgene in water due to rapid hydrolysis is substantiated by other
laboratory studies on the gas phase hydrolysis of phosgene (Butler and Snelson, 1979).

Applicant's summary and conclusion

Conclusions:
Phosgene undergoes rapid hydrolysis in aqueous solutions. It is sparingly soluble in water and
reacts with water very rapidly. These characteristics make it difficult to accurately define water
solubility estimates and octanol-water partition coefficients. Modeled data (EPIWIN) for water
solubility and partition coefficients provide inaccurate estimates for these parameters because the
models do not take into account the rapid hydrolysis of phosgene in aqueous solutions.