Registration Dossier
Registration Dossier
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EC number: 209-502-6 | CAS number: 583-39-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary literature
Data source
Reference
- Reference Type:
- other: secondary source
- Title:
- A review of the environmental impact and toxic effects of the given test chemical
- Author:
- Hassen et al.
- Year:
- 1 991
- Bibliographic source:
- Environmental protection division BC Environment Victoria British columbia,Octomber 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Principles of method if other than guideline:
- The acute toxicity study was conducted to evaluate the toxic effects of the given test chemical in rats by the inhalation route.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Benzimidazole-2-thiol
- EC Number:
- 209-502-6
- EC Name:
- Benzimidazole-2-thiol
- Cas Number:
- 583-39-1
- Molecular formula:
- C7H6N2S
- IUPAC Name:
- 1H-benzimidazole-2-thiol
- Details on test material:
- - Name of test material : 2-Mercaptobenzimidazole
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- 1270 mg/m3
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 1 270 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: non toxic by inhalation route
- Mortality:
- not specified
- Clinical signs:
- other: not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The LC50 value was considered to be >1270 mg/m3 when rats were treated with the given test chemical by inhalation route for 4 hours.
- Executive summary:
Acute inhalation toxicity study was conducted by using the given test chemical in rats at the dose concentration of 1270 mg/m3 via inhalation route for 4 hours of exposure.
Animals were observed for mortality. No mortality was observed at 1270 mg/m3 in treated animals.
Hence, the LC50 value was considered to be >1270 mg/m3 when rats were treated with the given test chemical by inhalation route for 4 hours.
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