Registration Dossier
Registration Dossier
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EC number: 281-339-3 | CAS number: 83929-47-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Relating to nominal concentrations of submission substance:
LC0 (96h): 220 mg/L;
LC50 (48 and 96h): > 500 mg/L
Key value for chemical safety assessment
Additional information
In a 96 hour acute toxicity test with Danio rerio equivalent to OECD 203 and compliant to GLP (reliability category 2), toxicity of the submission substance to freshwater fish was tested. Due to the poor solubility of the test item in water the dispersion of the test substance was not stable and precipitation caused a rapid decline in test substance concentration to 0.4 to 2.3% of nominal concentration during 24 hours. Therefore, a semistatic test design was applied with media exchange every 24 hours and effect concentrations are based on the nominal concentrations of submission substance applied. Only at the highest concentration applied 20% mortality had been observed after 48 and 96 hours. No mortality in the control and the solvent control was observed. At both tested concentrations observation of symptoms was restricted due to turbidity of the test medium. However, at both concentrations abnormalities in behaviour were observed. The following effect values had been determined (relating to nominal concentrations of submission substance):
LC0 (96h): 220 mg/L,
LC50 (48 and 96h): > 500 mg/L
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