Registration Dossier

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011-12-14 to 2011-12-21
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2008
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
signed 2010-10-20
Type of method:
flask method
Key result
Water solubility:
123.2 mg/L
Temp.:
20 °C
pH:
ca. 6.77
Remarks on result:
other: Deviation [%]: 8.56
Water solubility:
106.1 mg/L
Temp.:
30 °C
pH:
ca. 6.87
Remarks on result:
other: Deviation [%]: 4.84
Details on results:
Validity Criteria
The study was performed based on OECD Guideline 105 for Testing of Chemicals (1995) and Council Regulation (EC) No. 440/2008, Method A.6. The validity criteria were fulfilled:
- The concentration measured in at least the last two test vessels differed for no more than 15 %.
- No tendency of increasing values from sampling intervals of 24 – 72 h was measured.
- Temperatures were kept constant within ± 0.1 °C for definitive testing, during the preincubation phase the temperature was slightly below the given range at 00:39 (34.80 °C) and 10:39 (34.83 °C) on 2011-12-18 corresponding to a total span of 8 % of the shortest preincubation time of 24 h. This deviation does not have an effect on test results

Preliminary Test
In the preliminary testing the solubility of the test item was determined to be between 50 and 100 mg/L.

Main Test
All samples were checked negative for colloidal material using the Tyndall effect.

table: Solubility Results at 30°C

Sample Replicate No.

test substance [mg/L]

Meas.conc. Mean
24 h    1 105.0 103.4
2 101.7
48 h    1 111.2 108.4
2 105.6
72 h    1 103.1 106.4
2 109.6
Mean (24-72 h)            106.1
Deviation [%]1 4.84

able: Solubility Results at 20°C

Sample Replicate No.

test substance [mg/L]

Meas.conc. Mean
24 h    1 153.92 121.3
2 121.3
48 h    1 130.5 129.3
2 128.1
72 h    1 120.8 119.1
2 117.3
Mean (24-72 h)            123.2
Deviation [%]1 8.56

1) = Calculated

2) = Determined to be an outlier via GRUBBS-test, not taken into account

Meas. conc. = measured concentration (dilution factor of 1000 taken into account)

Conclusions:
According to Regulation EC 440/2008 Method A.6 and OECD 105 the solubility of the test item was determined to be 106.1 mg/L (pH 6.87) at 30 ± 0.1 °C and 123.2 mg/L (pH 6.77) at 20 ± 0.1 °C.
The mean solubility was determined to be 114.7 mg/L. A significant (> 3%/°C) temperature dependence of the solubility of the test item was not observed. The substance is considered to be moderately soluble.

Description of key information

key data water solubility: 123.2 mg/L (pH 6.77) at 20 ± 0.1 °C; 106.1 mg/L (pH 6.87) at 30 ± 0.1 °C. The test item is moderately soluble.

Key value for chemical safety assessment

Water solubility:
123.2 mg/L
at the temperature of:
20 °C

Additional information

According to Regulation EC 440/2008 Method A.6 and OECD 105 the solubility of the test item was determined to be 106.1 mg/L (pH 6.87) at 30 ± 0.1 °C and 123.2 mg/L (pH 6.77) at 20 ± 0.1 °C. The mean solubility was determined to be 114.7 mg/L. A significant (> 3%/°C) temperature dependence of the solubility of the test item was not observed.

Categories Display