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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: Expert evaluation; review
Type of information:
other: Reviews
Adequacy of study:
supporting study
Reliability:
other: Reviews
Rationale for reliability incl. deficiencies:
other: Published conclusions by different expert groups

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
OECD/SIDS. Screening Information Data Set (SIDS) of OECD High Production Volume Chemicals Programme, CAS Number 37971-36-1
Author:
OECD/SIDS
Year:
1994
Bibliographic source:
UNEP Publications
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1994

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Results and discussion

Results: P0 (first parental animals)

Effect levels (P0)

open allclose all
Dose descriptor:
other: Review on all available data
Basis for effect level:
other: see 'Remark'
Remarks on result:
not measured/tested
Remarks:
Effect level not specified Generation not specified (migrated information)
Dose descriptor:
other: Review on all available data
Basis for effect level:
other: BUA concluded that 2-phosphonobutane-1,2,4-tricarboxylic acid has no toxic potential and no risk to humans could be deduced.
Remarks on result:
not measured/tested
Remarks:
Effect level not specified Generation not specified (migrated information)

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion

Executive summary:

OECD/SIDS concluded:

"The available information on toxicity gave no evidence of damage in doses up to 375 mg/kg body weight. There is no evidence of embryo-toxicity, teratogenicity or genotxicity. Based on the available data on toxicity and the data on occupational exposure and exposure of the general population, 2-phosphonobutane-1,2,4-tricarboxylic acid is of low concern."

BUA concluded that 2-phosphonobutane-1,2,4-tricarboxylic acid has no toxic potential and no risk to humans could be deduced.

In aqueous media, PBTCNa4 and PBTC dissociate into the corresponding anion (2-phosphonatobutane-tricarboxylate ion) and the sodium ion and hydrogen ion (proton), respectively. The toxicological properties of PBTC and its tetrasodium salt are thought to be an effect of the phosphonato-carboxylate ion rather than of the sodium ion or the hydrogen ion (proton), which are normal constituents in body fluids and have no relevant toxic properties in low concentrations.

Therefore a read-across between PBTCNa4 and PBTC acid is justified.