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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
Version / remarks:
Method B
Deviations:
no
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
microscopic examination
Type of distribution:
mass based distribution
Mass median aerodynamic diameter:
122 µm
Key result
Percentile:
D50
Mean:
122 µm
Remarks on result:
other: Median diameter corresponds to MMAD (Mass Median Aerodynamic Diameter).(migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)

The sample was first sieved by a 100 µm sieve.

weighted sample: 1,61895 g

weight fraction <100 µm: 0.0008 g

mass fraction <100 µm: 0.05 %

The mass fraction <100 µm was 0.05 %, and was investigated by scanning electron microscopy. The median aspect ratio was 1.39 with 1.33 as standard deviation.

The median diameter of the particle size is given for the fraction <100 µm. The value 122 µm was calculated for cubical and for sherical particles.

 Particle Size  Spherical Voume[%]  Cubical Volume[%]
 <4 µm (respirable)  0.00  0.00
 4 - 10 µm (thoracic)  0.09  0.11
 10 - 100 µm (inhalable)  29.63  33.36
 >100 µm*)  70.28  66.53
Median (diameter µm)  122.37  120.96

   

*) These Particles belong to the sieve fraction < 100 μm. Particles with an aspect ratio >1 (e.g. long and thin particles) may have a greater mean diameter than the sieve fraction of 100μm.

Conclusions:
The MMAD (Mass Median Aerodynamic Diameter < 100 μm) has a value of 122.37 μm as spherical particles. All particles with a mean diameter less than 100µm have a mass fraction of 0.01 %. 0.0 % of this mass fraction has a mean diameter less than 10 μm.
Executive summary:

According to OECD guideline 110, the particle size distribution of tetrasodium hydrogen 2-phosphonatobutane-1,2,4-tricarboxylate was determined by scanning eletron microscopy method for the sieved fration and presented on the basis of calculated mass fractions referring to the total sample weight. All particles with a mean diameter less than 100µm have a mass fraction of 0.01 %. 0.0 % of this mass fraction has a mean diameter less than 10 μm. The mass mediam diameter is 122.37 µm (spherical volume) and 120.96 µm (cubial volume).

Description of key information

The MMAD (Mass Median Aerodynamic Diameter < 100 μm) has a value of 122.37 μm as spherical particles. Accounting on the total sample weight the fraction <4 µm (respirable) and the fraction 4 -10 µm (thoracic) was 0 % . The fraction of 10 -100 µm (inhalable) was 0.01% .

Additional information

According to OECD guideline 110, the particle size distribution of tetrasodium hydrogen 2-phosphonatobutane-1,2,4-tricarboxylate was determined by scanning eletron microscopy method for the sieved fration and presented on the basis of calculated mass fractions referring to the total sample weight. All particles with a mean diameter less than 100µm have a mass fraction of 0.01 %. 0.0 % of this mass fraction has a mean diameter less than 10 μm. The mass mediam diameter is 122.37 µm (spherical volume) and 120.96 µm (cubial volume).