4,6-dichloropyrimidine

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study acceptable for assessment, basic data given

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1991

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

yes

Test type:

other: Acute Range Dermal Toxicity

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4,6-dichloropyrimidine

EC Number:

214-770-2

EC Name:

4,6-dichloropyrimidine

Cas Number:

1193-21-1

Molecular formula:

C4H2Cl2N2

IUPAC Name:

4,6-dichloropyrimidine

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Type of coverage:

not specified

Vehicle:

water

Remarks:

deionized

Doses:

2000 mg/kg bw
400 mg/kg bw

No. of animals per sex per dose:

2 males
2 females

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 400 - < 2 000 mL/kg bw

Based on:

test mat.

Remarks on result:

other: Toxicity at a limit dose of 2000 mg/kg could not be determined due to the severity of irritation response seen at this dose level.

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Based on the data the LD50 for the acute dermal toxicity of the TS is considered to be greater than 400 mg/kg bw in rats.
Further on it may be concluded that the LD50 is less than 2000 mg/kg bw. As the toxicity can not be determined at the limit dose of 2000 mg/kg bw
the TS should be classified as Xn; R 21 (harmful in contact with skin) for precautionary reasons.