4,6-dichloropyrimidine

Guidance on Safe Use

First-aid measures

Inhalation: Get medical attention immediately. Move exposed person to fresh

air. If it is suspected that fumes are still present, the rescuer should

wear an appropriate mask or self-contained breathing apparatus.

Keep person warm and at rest. If not breathing, if breathing is

irregular or if respiratory arrest occurs, provide artificial respiration or

oxygen by trained personnel. It may be dangerous to the person

providing aid to give mouth-to-mouth resuscitation. If unconscious,

place in recovery position and get medical attention immediately.

Maintain an open airway. Loosen tight clothing such as a collar, tie,

belt or waistband. In case of inhalation of decomposition products

in a fire, symptoms may be delayed. The exposed person may need

to be kept under medical surveillance for 48 hours.

Ingestion: Get medical attention immediately. Wash out mouth with water.

Move exposed person to fresh air. Keep person warm and at rest.

If material has been swallowed and the exposed person is

conscious, give small quantities of water to drink. Stop if the

exposed person feels sick as vomiting may be dangerous. Do not

induce vomiting unless directed to do so by medical personnel. If

vomiting occurs, the head should be kept low so that vomit does not

enter the lungs. Chemical burns must be treated promptly by a

physician. Never give anything by mouth to an unconscious person.

If unconscious, place in recovery position and get medical attention

immediately. Maintain an open airway. Loosen tight clothing such

as a collar, tie, belt or waistband.

Skin contact: Get medical attention immediately. Flush contaminated skin with

soap and water. Remove contaminated clothing and shoes.

Continue to rinse for at least 10 minutes. Chemical burns must be

treated promptly by a physician. In the event of any complaints or symptoms, avoid further exposure. Wash clothing before reuse. Clean

shoes thoroughly before reuse.

Contact with the hot melt: cooling immediately with plenty of water. Do not remove product crusts which may have formed neither forcibly nor by  applying any solvents to the skin involved. In order to obtain medical care for possible burns and for smooth cleansing of the skin, seek medical advice immediately.

Eye contact: Get medical attention immediately. Immediately flush eyes with

plenty of water, occasionally lifting the upper and lower eyelids.

Check for and remove any contact lenses. Continue to rinse for at

least 10 minutes. Chemical burns must be treated promptly by a

physician.

Notes to physician: Basic aid, decontamination, symptomatic treatment.

Fire-fighting measures

Extinguishing media: In case of fire, use CO2, water spray (fog), foam, dry chemical.

Not suitable: Do not use water jet.

Special exposure hazards: no specific fire or explosion hazard.

Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any persoanal risk or without suitable training. This material is very toxic to aquatic organisms. Fire water contaminated with this material must be contained and prevented from being discharged to any waterway, sewer or drain.

Hazardous combustion products: Decomposition products may include the following materials:

carbon oxides

nitrogen oxides

halogenated compounds

Special protective equipment for fire-fighters: Fire-fighters should wear appropriate protective equipment and selfcontained

breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode.

Remark: Container explosion may occur under fire condition or when heated. Cool closed containers exposed to fire with water. When extinguishing with water pay attention to caustic burns.

Accidental release measures

Personal precautions: No action shall be taken involving any personal risk or without

suitable training. Keep unnecessary and unprotected personnel from

entering. Do not touch or walk through spilt material. Provide adequate ventilation. Put on

appropriate personal protective equipment.

Environmental precautions: Avoid dispersal of spilt material and runoff and contact with soil,

waterways, drains and sewers. Inform the relevant authorities if the

product has caused environmental pollution (sewers, waterways, soil

or air). Very toxic to aquatic organisms, may cause long-term adverse effect in the aquatic environment.

Large spill: Move containers from spill area. Prevent

entry into sewers, water courses, basements or confined areas.

Vacuum or sweep up material and place in a designated, labelled waste container. Dispose of via a licenced waste disposal contractor.

Small spill:  Move containers from spill area. Vacuum or sweep up material and place in a designated, labelled waste container. Dispose of via a licenced waste disposal contractor.

Handling and storage

Manufacture and use of this chemical intermediate takes place under strictly controlled conditions, as described in Art. 17/18 REACH. The substance is rigorously contained during manufacturing and use and appropriate risk management measures including PPE (i.g. during charging or sampling) are applied. Occupational exposure is reduced to a minimum and well controlled by measurements. A management system covering all general aspectsof a chemical production is in place, especially cleaning and maintenance of plants and equipment. An authorisation scheme based on instructions covering the whole process ensures that only trained and authorised staff handles the substance.

Handling:

Put on appropriate personal protective equipment. Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Persons with a history of skin sensitization problems should not be employed in any process in which this product is used. Do not get in eyes or on skin or clothing. Do not ingest. Avoid release to environment. Use only with adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Empty containers retain product residue and can be hazardous.

Storage:

Do not store below the following temperature: 100 °C (212°F). Store in accordance with local regulations. Store in original container. Store in a dry place. Keep contaner tightly closed and sealed until ready for use.  

Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination.

Packaging materials Recommended :

Use original container.

Remarks: Ensure effective ventilation. Vent waste air only via suitable separators or scrubbers. Take precautionray measures against electrostatic discharges.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

1760

Shipping information

Proper shipping name and description:

Corrosive liquid, N.O.S., molten (4,6-dichloropyrimidine)

Chemical name:

4,6-dichloropyrimidine

Language:

English

Labels:

corrosive, dangerous to the environment

Special provisions / remarks

Remarks:

Hazard identification number: 80
Limited quantity: LQ0

Inland waterway transport (UN RTDG/ADN(R))

UN number:

1760

Shipping information

Proper shipping name and description:

Corrosive liquid, N.O.S., molten (4,6-dichloropyrimidine)

Chemical name:

4,6-dichloropyrimidine

Language:

English

Labels:

corrosive, dangerous to the environment

Special provisions / remarks

Remarks:

Hazard identification number: 80
Limited quantity: LQ0

Marine transport (UN RTDG/IMDG)

UN number:

1760

Shipping information

Proper shipping name and description:

Corrosive liquid, N.O.S., molten (4,6-dichloropyrimidine)

Chemical name:

4,6-dichloropyrimidine

Labels:

corrosive, dangerous to the environment

Marine pollutant

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

--

Shipping information

Proper shipping name and description:

--

Chemical name:

--

Labels:

--

Special provisions / remarks

Remarks:

Air transport ICAO/IATA: Forbidden

Additional transport information

Additional information

Special provisions / remarks / other:

Corrosive,
Has a slight odour
Hot melt; risk of skin burns
Keep dry
Keep away from foodstuffs, acids and alkalis

The producer uses packaging for the product, which meets the requirements for products with a hazard potential as far as
tightness and stability are concerned. Consequently transport is possible without increased danger as long as attention is paid to the usual
measures such as stack height, protection against falling and correct labelling. In case of partially fractured containers, these must be kept closed carefully on any transport, in order to prevent spillage.

Exposure controls / personal protection

Exposure limit values:

Ingredient name: Phosphoryl trichloride, CAS 10025-87-3, Occupational expsosure limits (TRGS900 AGW (Germany, 7/2009):

TWA: 1.3 mg/m3 - 8 hour(s)

PEAK: 1.3 mg/m3 - 15 minute(s)

TWA: 0.2 ppm - 8 hour(s)

PEAK: 0.2 ppm - 15 minute(s)

Recommended monitoring procedures:

If this product contains ingredients with exposure limits, personal, workplace atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Reference should be made to European Standard EN 689 for methods for the assessment of exposure by inhalation to chemical agents and national guidance documents for methods for the determination of hazardous substances.

Risk management measures

Occupational exposure controls

Technical measures:

Use only with adequate ventilation. If user operations generate dust, fumes, gas, vapour or mist, use process enclosures, local exhaust ventilation or other engineering controls to keep worker expsoure to airborne contaminants below any recommended or statutory limits.

The substance shall be rigorously contained by technical means during its whole lifecycle including manufacture, sampling, analysis, loading and unloading of equipment or vessels, waste disposal or purification and storage. Procedural and control technologies sahll be used that minimise emission and the resulting exposure during purification or cleaning and maintenance procedures.

Organisational measures: Only properly trained and authorised personnel shall hanlde the substance. In case of cleaning and maintenance works, special procedures such as purging and washing shall be applied before the system is opened and entered. Substance-handling procedures shall be well documented and strictly supervised.

Personal protection measures

Respiratory protection:

Use a properly fitted, air-purifying or air-fed respirator complying with an approved standard if a risk assessment indicates this is necessary. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. Recommended:

Full mask with type ABEK-P2 filter.

Hand protection:

Chemical-resistant, impervious gloves or gauntlets complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. After contamination with product change the gloves immediately and dispose of them according to relevant national and local regulations <1 hours (breakthrough time): Butyl rubber - IIR, Fluorinated rubber -FKM or Polyvinyl chloride - PVC

Eye protection :

Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists, gases or dusts. Recommended: Tightly fitting safety goggles.

Skin protection:

Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product. Recommended: Wear protective clothing.

Hygiene measures :

Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location.

Environmental exposure controls

Technical measures:

Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels.

Stability and reactivity

Stability:

The product is stable.

Possibilty of hazardous reactions: Under normal conditions of storage and use, hazardous reactions will not occur.

Conditions to avoid:

Reactive with amines, alkalis and alcohols

Hazardous decomposition products:

Under normal conditions of storage and use, hazardous decomposition products should not be produced.

Disposal considerations

Methods of disposal:

Examine possibilities for re-utilisation. Product residues and uncleaned empty containers should be packaged, sealed, labelled, and disposed of or recycled according to relevant national and local regulations. Where large quantities are concerned, consult the supplier. When uncleaned empty containers are passed on, the recipient must be warned of any possible hazard that may be caused by residues. For disposal within the EC, the appropriate code according to the European Waste List (EWL) should be used. It is among the tasks of the polluter to assign the waste to waste codes specific to industrial sectors and processes according to the European Waste List (EWL).

Hazardous waste:

The classification of the product may meet the criteria for a hazardous waste.