Dipotassium heptafluorotantalate

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

other: Handbook data

Adequacy of study:

supporting study

Study period:

Not stated

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Peer reviewed handbook citing toxicological data as found in the literature. Information provided is based on a suitable read-across substance.

Data source

Reference

Reference Type:

review article or handbook

Title:

Metal Toxicity in Mammals 2 Chemical Toxicity of Metals and Metalloids

Author:

Venugopal B & Luckey T D

Year:

1978

Bibliographic source:

Ch. 5 pg. 205-6 and 229-231

Materials and methods

Principles of method if other than guideline:

Data is taken from a handbook and therefore has no specific information regarding methodology.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Potassium tantalate

IUPAC Name:

Potassium tantalate

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Details on study design:

A non standard method was used; 8 mg of potassium tantalate was mixed with mixed with NaCl and introduced to rats via a stomach tube.

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:

Ta compounds display low gastrointestinal solubility in rats.

Details on distribution in tissues:

Retention of Ta in mammalian tissue is more prolonged in comparison with other metals in Group V. The order of retention in ascending order: bones, gastrointestinal tract, pelt, muscle, liver, kidneys, testes then spleen. Tantalum held in the bones accounts for 40% of the body content (Fleshman et al., 1971).
There are no reports of Ta accumulation in tissue.
There are no reported homeostatic excretory pathways.

Details on excretion:

Soluble potassium tantalate was eliminated in three phases; rapid elimination of unabsorbed tantalate, slow elimination of loosely bound tantalate in the tissue, and a 3-4 day elimination of minute quantities of tightly bound tantalum.

Metabolite characterisation studies

Metabolites identified:

not specified

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
Under the conditions of the test potassium tantalate is excreted within the faeces in 3 phases, when fed to rats. Bioretention can be prolonged in comparison to other Group V Metals, however specific information is not given. Bioaccumulation is greatest in the bones, then in descending order; gastrointestinal tract, pelt, muscle, liver, kidneys, testes then spleen. Again no specific data is presented about bioaccumulation. It is also stated that gastrointestinal absorption of Ta salts is relatively low in rats.

Executive summary:

Under the conditions of the test potassium tantalate is excreted within the faeces in 3 phases, when fed to rats; rapid excretion of unabsorbed tantalate, slow elimination of loosely bound tantalum in tissues and a 3 to 4 day elimination of minute quantities of tightly bound tantalum.

Bioretention can be prolonged in comparison to other Group V Metals, however specific information is not given. Bioaccumulation is greatest in the bones, then in descending order; gastrointestinal tract, pelt, muscle, liver, kidneys, testes then spleen; again no specific data is presented about bioaccumulation. It is also stated that gastrointestinal absorption of Ta salts is relatively low in rats.