Registration Dossier
Registration Dossier
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EC number: 221-221-0 | CAS number: 3033-77-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
In a activated sludge respiration inhibition test (OECD 209) performed in 2002. EC10-value of 443 mg/l estimated with regression analysis according to Cavalli-Sforza (1972) has been presented in the test report and this will be used for the PNEC derivation.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 2 000 mg/L
- EC10 or NOEC for microorganisms:
- 443 mg/L
Additional information
EPTAC is only slightly toxic to micro-organisms. In a activated sludge respiration inhibition test (OECD 209) performed in 2002 no EC50-value could be found with the highest test concentration of 2000 mg/L. EC10-value of 443 mg/l estimated with regression analysis according to Cavalli-Sforza (1972) has been presented in the test report and this will be used for the PNEC derivation.
In addition to the respiration inhibition test the effect of EPTAC on the dehydrogenase activity of active sludge has been tested (Degussa, 1988). However, this test does not fulfil the requirements for the micro-organisms toxicity test, since it only measures the inhibition of dehydrogenase activity of the sludge. Many micro-organisms can suffer or even be dead although the enzyme activity can be detected. Therefore this study can not be used in derivation of PNEC micro-organisms.
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