Registration Dossier
Registration Dossier
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EC number: 203-402-6 | CAS number: 106-48-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1960
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication.
Data source
Reference
- Reference Type:
- publication
- Title:
- The metabolism of halogenated benzenes: (a) penta- and hexachlorbenzenes. (b) further observations on 1:3:5-trichlorobenzene.
- Author:
- Parke DV, Williams RT
- Year:
- 1 960
- Bibliographic source:
- Biochem J 74:5-9 (Studies in Detoxication [81])
Materials and methods
- Principles of method if other than guideline:
- Investigation of the metabolic fate of penta and hexa-chlorobenzene in rabbits.
- GLP compliance:
- no
- Remarks:
- prior to GLP
Test material
- Reference substance name:
- 1,2,3,4,5-pentachlorobenzene / 608-93-5
- IUPAC Name:
- 1,2,3,4,5-pentachlorobenzene / 608-93-5
- Reference substance name:
- Hexachlorobenzene / 118-74-1
- IUPAC Name:
- Hexachlorobenzene / 118-74-1
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- Chinchilla
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Diet: 80 g/day (rat cubes, diet 41 Associated London Flour Millers)
- Water: 100 mL/day
Administration / exposure
- Route of administration:
- other: stomach tube as aqueous suspensions or subcutaneously as 10 % (w/v) solutions arachis oil
- Details on dosing and sampling:
- Urine was collected daily.
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Chromatographic evidence was obtained that 4-chlorophenol and 4-chlorocatechol are minor urinary metabolites.
Any other information on results incl. tables
Results:
1,2,3,4,5-pentachlorobenzene is only slightly altered in vivo, and hexachlorobenzene seems to be metabolically inert.
Studies of these highly chlorinated benzenes have been carried out in connection with work in this Laboratory on the metabolism of the highly chlorinated insecticides, dieldrin and aldrin, which also appear to be metabolically inert.
The substance 1,2,3,4,5-pentachlorobenzene does not have any important practical application, but hexachlorobenzene has limited use as a fungicidal agent for seeds.
Jondorf et al.(1955) were unable to account for the major portion of the dose of 1:3:5-trichlorobenzene given to rabbits. This compound has been re-investigated and it is now clear that it is not readily metabolized.
Applicant's summary and conclusion
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