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EC number: 204-625-1 | CAS number: 123-41-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Density
Administrative data
Link to relevant study record(s)
- Endpoint:
- relative density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-03-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented guideline study (OECD 109) without restrictions.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- pycnometer method
- Type:
- relative density
- Density:
- 1.08
- Temp.:
- 20 °C
- Remarks on result:
- other: The relative density was determined to be 1.08 ± 0.01
- Conclusions:
- The density of a 45% solution of choline hydroxide was determined in an OECD 109 guideline study, classified as reliable without restrictions. Hence, the results in general are considered as reliable and can be used for further risk assessment. Although the salt choline hydroxide is a solid compound, it is very hygroscopic and cannot be kept water-free under normal environmental conditions. Furthermore, it is marketed as an 45 % aqueous solution and is therefore the predominantly available form. Hence, it is justified out of scientific reasons and exposure considerations to regard choline hydroxide as aqueous solution. The outcome of this study is considered reasonable and within the scientifically expected ranges, the results are considered as valid because of their reproducibility.
- Executive summary:
The relative density D(20/4) of a 45 % aqueous solution of choline hydroxide was determined according to OECD Guideline 109 (Density of Liquids and Solids / pycnometer method) to be 1.08 ± 0.001 at 20 °C ± 0.9 °C. D(20/4) describes the density of the substance at 20 °C in proportion to the density of water at 4 °C. The determination of the density of the aqueous solution of choline hydroxide is justified out of scientific reasons and exposure considerations and the results are within the scientifically expected range. The study was classified as Klimisch 1 and meets fully the OECD 109 guideline requirements.
Reference
Determination of the relative density
Measurements
Density of water at 20°C = 0.99821 g/mL (X); Density of water at 4°C = 1g/mL (Y)
|
Test 1 |
Test 2 |
Weight of pycnometer (A) g |
20.4521 |
22.9409 |
Weight of pycnometer + water (B) g |
44.9200 |
47.8684 |
Weight of pycnometer (A1) g |
20.4518 |
22.9407 |
Weight of pycnometer + test substance (C) g |
46.9254 |
49.8688 |
Calculations Used to Determine Relative Density
Volume of pycnometer (mL) V = (B - A) / X
Density of test substance (g/mL) D1 = (C - A1) / V
Relative density D (20/4) = D1 / Y
Results
Using the values and equations above, the relative density for Tests 1 and 2 were calculated.
Test1 |
Test2 |
|
Volume of pycnometer (mL) (V) |
24.5118 |
24.9722 |
Density of test substance (D1) |
1.0800 |
1.0783 |
Relative Density (D1/Y) |
1.0800 |
1.0783 |
Mean relative density reported as 1.08 ± 0.01 at 20°C ± 0.5°C.
Description of key information
Density of the aqueous solution of Choline hydroxide: 1.08 ± 0.01 at 20 ± 0.5 °C (OECD Guideline 109 (Density of Liquids and Solids))
Key value for chemical safety assessment
- Relative density at 20C:
- 1.08
Additional information
The density of a 45 % solution of choline hydroxide was determined in an OECD 109 guideline study, classified as reliable without restrictions (Klimisch 1) and which meets fully the OECD 109 guideline requirements. Hence, the results in general are considered as reliable. The relative density D(20/4) describes the density of the substance at 20 °C in proportion to the density of water at 4 °C.
Although the salt choline hydroxide is a solid compound, it is very hygroscopic and cannot be kept water-free under normal environmental conditions. Furthermore, it is marketed as an 45 % aqueous solution and is therefore the predominantly available form. Hence, it is justified out of scientific reasons and exposure considerations to regard choline hydroxide as aqueous solution. The outcome of this study is considered reasonable, within the scientifically expected ranges, the results are considered as valid because of their reproducibility and can be used for further risk assessment.
Due to the reliability of the results and the choice of the test item with regard to the predominantly existing form of choline hydroxide, i.e. a 45 % aqueous solution, the tonnage-driven requirements under REACH are fully met, no datagaps were identified and no further testing is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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