Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 421-450-8 | CAS number: 154702-15-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Chemical name of vehicle (organic solvent: Dimethylsulfoxide (DMSO)
- Concentration of vehicle in test medium: 0.1 mL DMSO/L - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Every week a number of cultures is started with ca. 125 daphnias of the same age (about one day) in ca. 4 litres of dilution water. The cultures are fed daily with ca. 4x10^9 algal cells (chlorella) and ca. 0.13 grams of yeast per 4 litre. The medium is completely replaced at least once a week; at the same time all young born are removed. The cultures are kept at 20+/-1°C under a 16h light and 8h dark regime with transition periods of ca. 30 minutes. After 4 weeks the cultures are discarded.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 202 mg/L
- Test temperature:
- The temperature in one of the control vessels was measured at the beginning and at the end of the test. The temperature in the test vessels was 19.9 at the beginning and 20.6 °C at the end of the test.
- pH:
- The pH concentration was measured at the beginning and at the end of the test. pH concentration was also measured after 24h in all test media, in which all animals were immobile. The pH varied between 8.0 and 8.3.
- Dissolved oxygen:
- The oxygen concentration was measured at the beginning and at the end of the test. Oxygen concentration was also measured after 24h in all test media, in which all animals were immobile. The lowest value measured was 8.2 mg/L.
- Details on test conditions:
- The test was carried out under a 16h light- 8h dark regime with transition periods of ca. 30 minutes in a temperature controlled room.
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1.88 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Conclusions:
- After 48h a few daphnias were dead at dosed amounts of 3.2, 5.6 and 10 mg/L. This mortality (10% or less) can most likely be attributed to the presence of undissolved material, causing physical hampering of the test organisms. Indications for this phenomenon were obtained in the range finding test, although this could not be visually assessed in the final test. Furthermore, because 10% immobility (in the control) is allowed according to the OECD guideline no. 202, this mortality is not taken into account. It is concluded that the test substance is not acutely toxic to Daphnia magna, with respect to mobility and condition, when exposed at its aqueous solubility level.
Reference
Description of key information
Freshwater, 48-h EC50 > 1.88 mg/L (measured concentration), static, Daphnia magna, mobility, OECD TG 202 and EU method C.2, 1997
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 1.88 mg/L
Additional information
An OECD TG 202 and EU method C.2 followed GLP study is available for this endpoint and used as key study representing freshwater. The 48-hour EC50 for mobility was determined to be > 1.88 mg/L based on measured concentrations (Reliability 1).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.