Diamminediisocyanatozinc

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

experimental study planned

Justification for type of information:

TESTING PROPOSAL ON VERTEBRATE ANIMALS
[Please provide information for all of the points below. The information should be specific to the endpoint for which testing is proposed. Note that for testing proposals addressing testing on vertebrate animals under the REACH Regulation this document will be published on the ECHA website along with the third party consultation on the testing proposal(s).]

NON-CONFIDENTIAL NAME OF SUBSTANCE:
- Name of the substance on which testing is proposed to be carried out : Diaminodiisocyanatozinc

CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION [please address all points below]:
- Available GLP studies : None
- Available non-GLP studies: None
- Historical human/control data : None
- (Q)SAR : Not available.
- In vitro methods : Not applicable.
- Weight of evidence : Not enough long-term data or other information available. Alternatively, see Endpoint summray "Aquatic Toxicity", given data on short-term and long-term aquatic toxicity are considered to be not sufficient.
- Grouping and read-across : No possible alternative structures available.
- Substance-tailored exposure driven testing [if applicable] : n/a
- Approaches in addition to above [if applicable]: n/a
- Other reasons [if applicable] : n/a

CONSIDERATIONS THAT THE SPECIFIC ADAPTATION POSSIBILITIES OF ANNEXES VI TO X (AND COLUMN 2 THEREOF) OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- According to REACH Annex IX column 2, appropriate long-term toxicity testing on aquatic invertebrates shall be proposed by the registrant if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on aquatic organisms.
A study according to OECD TG 202 with Daphnia magna is available for the short-term toxicity to aquatic invertebrates indicating an acute hazard to the auatic environment. With a factor of about 100 compared to algae or fish Daphnia magna also represents the most sensitive species based on the available short-term results. Therefore, a chronic reproduction study with Daphnia magna according to OECD TG 211 is considered most suitable for the determination of any long-term toxicity to aquatic invertebrates.


FURTHER INFORMATION ON TESTING PROPOSAL IN ADDITION TO INFORMATION PROVIDED IN THE MATERIALS AND METHODS SECTION:
- Details on study design / methodology proposed [if relevant]: The most meaningful study design will be elaborated with the study director of the appointed test facility based on the behaviour of the test item in the respective test medium and the results of related pre-experiments.

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 211 (Daphnia magna Reproduction Test)

Test material

Test material information

Constituent 1

Reference substance name:

Diamminediisocyanatozinc

EC Number:

401-610-3

EC Name:

Diamminediisocyanatozinc

Cas Number:

122012-52-6

Molecular formula:

C2H6N4O2Zn

IUPAC Name:

copper(2+) bis(carbonylazanide) diamine