Registration Dossier
Registration Dossier
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EC number: 222-158-1 | CAS number: 3373-59-9
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-03-19 to 2013-11-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Principles of method if other than guideline:
- The solubility in water is specified by the saturation mass concentration of the substance in water, and is a function of temperature. Solubility is specified in units of mass per volume of solution, and is reported as grams/litre (g/l).
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- Methyl L-threoninate
- EC Number:
- 222-158-1
- EC Name:
- Methyl L-threoninate
- Cas Number:
- 3373-59-9
- Molecular formula:
- C5H11NO3
- IUPAC Name:
- Methyl (2S,3R)-2-amino-3-hydroxy-butanoate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): L-threonine methyl ester
- Physical state: white crystalline powder
- Analytical purity: 99.8%
- Lot/batch No.: X5UYC99
- Expiration date of the lot/batch: July 2014
- Storage condition of test material: Frozen
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- > 500 g/L
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- NA
Any other information on results incl. tables
In a preliminary test, a portion (approximately 100 mg) of the test substance was found to dissolve readily in 200 μl of purified water, indicating a solubility of greater than 500 g/l of solvent. No further testing was considered necessary.
Applicant's summary and conclusion
- Conclusions:
- L-TME was found to have a solubility of greater than 500 g/l of water.
- Executive summary:
The water solubility of L-TME was measured in accordance to OECD 105. Results from preliminary testing indicated a water solubility of greater than 500 g/l of solvent, hence no further testing was performed and it was concluded that L-TME is very soluble in water.
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