Registration Dossier
Registration Dossier
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EC number: 217-232-5 | CAS number: 1783-81-9
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
No experimental data are available for the assessment of carcinogenicity of 3-(methylthio)aniline.
The structure activity relationship of the substance was investigated in silico by using the QSAR Toolbox 4.3.1 (released 2019).
The Toolbox refers to aromatic amine type compounds (primary aromatic amines, hydroxyl amines and their derived esters) for carcinogenicity.
Based on the structural similarity of 3-(methylthio)aniline to aniline (62 -53 -3) and the similarity of metabolism of both substances in rat liver simulated by the QSAR Toolbox, the experimental results for aniline will be taken over to 3 -(methylthio)aniline. Thus, 3 -(methylthio)aniline will be classified with Carc 2 (H351) in accordance to aniline as long as no experimental data are available for 3 -(methylthio)aniline itself.
Additional information
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