Registration Dossier
Registration Dossier
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EC number: 217-232-5 | CAS number: 1783-81-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
No experimental data are available for the assessment of skin and eye irritation properties of 3-(methylthio)aniline.
The structure activity relationship of the substance was investigated by using the QSAR Toolbox 4.3.1 (released 2019). The QSAR Toolbox refers to 'Aromatic amines' with regard to skin irritation according to the Inclusion rules by BfR (skin irritant). With regard to eye irritation the Exclusion rules by BfR (Group CNS, log Kow > 1.5) predict NON R36 (no eye irritant).
Based on the structural similarity of 3-(methylthio)aniline to aniline (62 -53 -3) and the similarity of metabolism of both substances in rat liver simulated by the QSAR Toolbox, the experimental results for aniline will be taken over to 3 -(methylthio)aniline. Thus, 3 -(methylthio)aniline will be classified with Eye Damage 1 (H318) in accordance to aniline as long as no experimental data are available for 3 -(methylthio)aniline itself.
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