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EC number: 265-777-2 | CAS number: 65442-31-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Structurally source and target substances are comparable, regarding the physico-chemical properties, source material seems to be likely more systemically bioavailable than 6-SBQ (target material). From a toxicity point of view, SBQ (source material) would therefore be expected to represent ‘worst-case’-scenarios.
- Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- The source material is Isobutylquinoleine. It is a mixure of 2 isomers.
The two isomers are 6-Sec-butylquinoline and 8-sec-butylquinoline. The target substance is 6-Sec-butylquinoline. - Irritation parameter:
- erythema score
- Basis:
- animal: #1, #2 and #3
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other:
- Remarks:
- No correction between the experimental result of tested material and the read-across target material.
- Irritation parameter:
- edema score
- Basis:
- animal: #1, #2 and #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Animal #1: slight fissures and desiccated skin by 72 hours and scar formations by day 7; Animal #1 and #2: moderate to slight scales between day 7 to 14; Animal #3: slight scales between day 7 to 14 and desiccated skin by 72 hours
- Remarks:
- No correction between the experimental result of tested material and the read-across target material.
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Remarks:
- No correction between the experimental result of tested material and the read-across target material.
- Conclusions:
- In a skin irritation study with rabbits, performed according to OECD 404 (1981), with the source material, irritation was observed, which was fully reversible within 14 days, although scaling was still present. Structurally source and target substances are comparable, regarding the physico-chemical properties, source material seems to be likely more systemically bioavailable than 6-SBQ (target material). From a toxicity point of view, SBQ (source material) would therefore be expected to represent ‘worst-case’-scenarios. Based on the results of this study, the source substance is considered a skin irritant: Category 2 (H315), the target material (6-sec-butylquinoline) can also be considered a skin irritant: Category 2 (H315).
- Executive summary:
The test source material was tested in a skin irritation test in 3 rabbits in accordance with OECD TG 404 (1981) test guideline and according to GLP principles. The mean value for erythema from gradings at 24, 48 and 72 hours after patch removal was 3 in all animals. For oedema, this mean value was 2 in all animals. No corrosive effect was observed. The irritation was fully reversible within 14 days, although scaling was still present. Based on the results of this study, the substance is considered a skin irritant. As source and target material are comparable, the same conclusion may be applicable for the target material 6 -sec-butylquinoline.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Structurally source and target substances are comparable, regarding the physico-chemical properties, source material seems to be likely more systemically bioavailable than 6-SBQ (target material). From a toxicity point of view, SBQ (source material) would therefore be expected to represent ‘worst-case’-scenarios.
- Reason / purpose for cross-reference:
- read-across source
- Specific details on test material used for the study:
- The source material is Isobutylquinoleine. It is a mixure of 2 isomers.
The two isomers are 6-Sec-butylquinoline and 8-sec-butylquinoline. The target substance is 6-Sec-butylquinoline. - Irritation parameter:
- cornea opacity score
- Remarks:
- (opacity)
- Basis:
- animal: #1 and #2 (mean)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other:
- Remarks:
- No correction between the experimental result of tested material and the read-across target material.
- Irritation parameter:
- cornea opacity score
- Remarks:
- (opacity)
- Basis:
- animal: #3 (mean)
- Time point:
- 24/48/72 h
- Score:
- > 0 - < 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: Corneal opacity was observed, only at 24 hours, but not enough for assigning a score of 1
- Remarks:
- No correction between the experimental result of tested material and the read-across target material.
- Irritation parameter:
- iris score
- Basis:
- animal: #1, #2 and #3 (mean)
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other:
- Remarks:
- No correction between the experimental result of tested material and the read-across target material.
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #1
- Remarks:
- (mean)
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other:
- Remarks:
- No correction between the experimental result of tested material and the read-across target material.
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #2
- Remarks:
- (mean)
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other:
- Remarks:
- No correction between the experimental result of tested material and the read-across target material.
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #3
- Remarks:
- (mean)
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other:
- Remarks:
- No correction between the experimental result of tested material and the read-across target material.
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1, #2 and #3 (mean)
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other:
- Remarks:
- No correction between the experimental result of tested material and the read-across target material.
- Irritant / corrosive response data:
- No correction between the experimental result of tested material and the read-across target material.
- Interpretation of results:
- GHS criteria not met
- Remarks:
- No correction between the experimental result of tested material and the read-across target material.
- Conclusions:
- In an eye irritation study with rabbits, performed according to OECD 405 (1981) with the source material, limited irritation was observed. Based on the results of this study, the substance does not need to be classified for eye irritation, in accordance with the CLP Regulation. Structurally source and target substances are comparable, regarding the physico-chemical properties, source material seems to be likely more systemically bioavailable than 6-SBQ (target material). From a toxicity point of view, SBQ (source material) would therefore be expected to represent ‘worst-case’-scenarios. Based on the results of this study, the source substance does not need to be classified for eye irritation, in accordance with the CLP Regulation. The target material (6-sec-butylquinoline) can also be considered as no eye irritation.
- Executive summary:
The test source material was tested in an eye irritation test in rabbits according to OECD 405 (1981). Slight ocular effects were observed, which were fully reversible within 7 days. The cornea and iris scores were<0.33. The conjunctival redness and conjunctival oedema following grading at 24, 48 and 72 hours after installation of the substance were 2 or lower, exept one animal, which scored 3 at the 24 h only. Therefore the substance is not considered an eye irritant. As source and target material are comparable, the same conclusion may be applicable for the target material 6 -sec-butylquinoline.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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