Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 266-942-1 | CAS number: 67701-23-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 August 2005 - 7 September 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Justification for read across, see attached document.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- Methods and investigations were performed in conformance with the OECD-Guideline 423, 17 December 2001 and the Directive 2004/73/EC, method B.1 tris.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Tall oil
- EC Number:
- 232-304-6
- EC Name:
- Tall oil
- Cas Number:
- 8002-26-4
- Molecular formula:
- Not applicable - UVCB substance
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)IGS BR.
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 300 (mg/kg b.w.) and 2000 (mg/kg b.w.)
- No. of animals per sex per dose:
- 3 per step (6 per dose)
- Control animals:
- no
Results and discussion
- Preliminary study:
- As no prior information on the toxicity of the test substance was available, a starting dose of 300 mg of the test substance per kg body weight was chosen.
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50, oral > 2000 mg /kg body weight
- Executive summary:
Aim of the study
The aim of the study was to investigate acute toxic effects of the test substance after a single peroral administration to rats.
Methods
Methods and investigations were performed in conformance with the OECD-Guideline 423, 17 December 2001 and the Directive 2004/73/EC, method B.1 tris.
Administration of the test substance
"CRUDE TALL OIL" was administered once as a solution in corn oil, given orally via gavage to female Crl:CD(SD)IGS BR rats.
The dosing was performed sequentially to groups of 3 animals per step using a starting dose of 300 mg per kg body weight and 2000 mg per kg body weight as the second dose.
The dose volume was 10 mL per kg body weight for all groups.
Investigations
• Body weights: before administration, 7 and 14 days after the administration (p.a.).
• Clinical observations: at least once per day.
• Necropsy: The animals were sacrificed and necropsied 14 days p.a.
Results
According to Commission Directive 2001/59/EC "CRUDE TALL OIL" does not require classification for acute oral toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
