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EC number: 240-166-3 | CAS number: 16026-16-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6th February - 15th May 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: turbidity method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: SOAP005-2
- Expiration date of the lot/batch: 15 October 2022
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Ambient, stored under nitrogen in a desiccator
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: Following receipt of the test item, it was found that the material readily absorbed moisture in the parent container. Consequently, on advice from the Sponsor, a sub-sample was dried overnight at 100°C and then stored in a desiccator under a headspace of nitrogen. - Water solubility:
- 45 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 5.4 - <= 7.1
- Details on results:
- The results were consistent with the visual observations on the samples, since at concentrations above the calculated solubility the solution were turbid.
- Conclusions:
- The water solubility of the test item was determined to be 45 mg/L at 20°C.
- Executive summary:
The water solubility study with Calcium bis[(Z)-N-methyl-N-(1-oxo-9-octadecenyl)aminoacetate] was conducted according to the OECD guideline 105 using a turbidity method (Dunning 2018). A preliminary test was conducted to assess the approximate solubility of the test item and ascertain the appropriate test procedure for the definitive testing. A solubility of less than 10 mg/L was estimated. The test item is a surface active substance, therefore a turbidity method was selected for the determination of the water solubility of the substance. The test was conducted in duplicate in a temperature controlled environmental chamber at 20°C.
The water solubility of the test item was determined to be 45 mg/L at 20°C.
The study is GLP-compliant and was conducted according to the standard guideline, therefore is considered reliable without restrictions and suitable as a key study for this endpoint.
Reference
Table 1 - Water solubility measurements (Sample A)
Point |
Concentration |
Mean turbidity |
pH |
ln concentration |
ln turbidity |
|
|
|
|
|
|
1 |
1017 |
178 |
5.5 |
6.92 |
5.18 |
2 |
508.6 |
51.1 |
5.6 |
6.23 |
3.93 |
3 |
254.3 |
16.2 |
5.7 |
5.54 |
2.79 |
4 |
127.2 |
9.97 |
5.9 |
4.85 |
2.30 |
5 |
63.58 |
11.1 |
6.4 |
4.15 |
2.41 |
61 |
31.79 |
8.20 |
5.9 |
3.46 |
2.10 |
7 |
15.89 |
1.07 |
7.1 |
2.77 |
0.06 |
8 |
7.947 |
0.789 |
6.9 |
2.07 |
-0.24 |
9 |
3.973 |
0.485 |
6.8 |
1.38 |
-0.72 |
10 |
1.987 |
0.253 |
7.0 |
0.69 |
-1.37 |
|
|
|
|
|
|
1Point 6 was excluded from the calculations as an outlier.
Linear regression of points 3 to 5, y = 0.272x + 1.18
Linear regression of points 5 to 9, y’ = 1.26x’ - 2.44
Table 2 - Water solubility measurements (Sample B)
Point |
Concentration |
Mean turbidity |
pH |
ln concentration |
ln turbidity |
|
|
|
|
|
|
1 |
1045 |
167 |
5.4 |
6.95 |
5.12 |
2 |
522.6 |
54.1 |
5.4 |
6.26 |
3.99 |
3 |
261.3 |
18.6 |
5.5 |
5.57 |
2.92 |
4 |
130.7 |
11.6 |
5.5 |
4.87 |
2.45 |
5 |
65.33 |
15.3 |
5.5 |
4.18 |
2.73 |
6 |
32.66 |
8.38 |
5.6 |
3.49 |
2.13 |
7 |
16.33 |
3.25 |
5.8 |
2.79 |
1.18 |
8 |
8.166 |
1.27 |
5.7 |
2.10 |
0.24 |
9 |
4.083 |
0.562 |
6.8 |
1.41 |
-0.58 |
10 |
2.041 |
0.308 |
6.7 |
0.71 |
-1.18 |
|
|
|
|
|
|
Linear regression of points 3 to 5, y = 0.142x + 2.01
Linear regression of points 5 to 9, y’ = 1.21x’ - 2.18
Description of key information
The water solubility of Calcium bis[(Z)-N-methyl-N-(1-oxo-9-octadecenyl) aminoacetate] is 45 mg/L at 20°C.
Key value for chemical safety assessment
- Water solubility:
- 45 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility study was conducted according to the OECD guideline 105 using a turbidity method (Dunning 2018).
The water solubility of the test item was determined to be 45 mg/L at 20°C.
The study is GLP-compliant and was conducted according to the standard guideline, therefore is considered reliable without restrictions and suitable as a key study for this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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