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Diss Factsheets
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EC number: 213-485-0 | CAS number: 957-68-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 26, 2012 to November 26, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study (OECD107) with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- < -3.4
- Temp.:
- 20 °C
- pH:
- ca. 4
- Details on results:
- The measurements of the Octanol phases produced a signal of the test item in the HPLC, which is not as clear as in the aqueous phases. Due to the presence of Octanol, the peak of the test item is overlaid by another signal, which was not observed in the aqueous phases or in the calibration. Although the integration of the test item signal for the Octanol phases is more conservative and should lead to higher concentrations, the concentrations of the tests 1a to 2b were below the lowest reasonable calibration standard with a concentration of 0.054275 mg/L.
- Conclusions:
- log Pow < -3.4
Pow < 0.0004 - Executive summary:
The partition coefficient at 20 °C of test item 7-Aminocephalosporanic acid was determined by the shake flask method, according to OECD Test Guideline 107 and EC No. 440/2008 Part A. Method A.8.
log Pow < -3.4
Pow < 0.0004
Reference
Table 4 shows the results of the main test for the determination of the partition coefficient.
The values represented in the table are rounded values. The calculation was carried out with the original not rounded values.
Table 4: Main test for the determination of the partition coefficient
Test |
1a |
1b |
2a |
2b |
3a |
3b |
c (aqueous phases) [mg/L] (measured values) |
131.13 / 131.03 |
131.97 / 130.94 |
84.70 / 84.54 |
83.58 / 83.45 |
262.25 / 261.76 |
257.66 / 257.41 |
c (aqueous phases, mean values) [mg/L] |
131.09 |
131.46 |
84.62 |
83.52 |
262.01 |
257.54 |
pH value of aq. phases (24°C) |
4.3 |
4.1 |
4.1 |
4.1 |
3.8 |
3.8 |
c (n-Octanol phases) [mg/L] (measured values) |
<0.05 / <0.05 |
<0.05 / <0.05 |
<0.05 / <0.05 |
<0.05 / <0.05 |
0.08 / |
0.08 / |
c (n-Octanol phases, mean values) [mg/L] |
<0.05 |
<0.05 |
<0.05 |
<0.05 |
0.08 |
0.08 |
Total recovery rate of the test item [%] |
88 |
89 |
86 |
84 |
88 |
87 |
POW |
<0.0004 |
<0.0004 |
<0.0006 |
<0.0006 |
0.0003 |
0.003 |
log POW |
<-3.4 |
<-3.4 |
<-3.2 |
<-3.2 |
-3.5 |
-3.5 |
Mean value log POW |
<-3.4 |
Description of key information
log Pow < -3.4
Pow < 0.0004
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -3.4
- at the temperature of:
- 20 °C
Additional information
The log Pow is not -3.4, as one is forced to enter in the field above, but the log Pow is <-3.4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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