3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

July 27, 2012 - September 18, 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study (OECD103) with acceptable restrictions

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

GLP compliance:

no

Type of method:

differential thermal analysis

Key result

Decomposition:

yes

Decomp. temp.:

>= 180 °C

In all three measurements a broad exothermal effect could be observed in a temperature range of 190 – 360 °C with a decomposition energy of -190 J/g (mean value). In all three measurements amass loss of approximately 68 % could be observed.

Table2:    Results on melting and boiling point

No.	Sample weight / mg	Start of effect / °C	Energy / J/g	Remark
PN4233	13.94	200	-190 (exothermal)
PN4242	10.58	210	-170 (exothermal)
PN4262	12.04	190	-210(exothermal)

Conclusions:

According to OECD Test Guidelines 102 and 103, and EC No. 440/2008 Part A. Method A.1. and A.2., the test item 7-Aminocephalosporanic acid has no melting and no boiling point at atmospheric pressure (1013 hPa). It decomposes firstly at a temperature of 180 °C.

Executive summary:

The test item decomposes at >=180 °C, without melting.

Description of key information

The test item decomposes at >=180 °C, without melting.