Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 915-372-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2018-03-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Please refer to the QPRF file provided under the section attached justification.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSAR R.6
- Principles of method if other than guideline:
- Estimation of the Hydrolysis Rate Constant using Trend analysis method in OECD QSAR Toolbox v4.2.
- GLP compliance:
- no
- Specific details on test material used for the study:
- SMILES: CCCCC(CC)COP(=O)(O)O
2-ethylhexyl dihydrogen phosphate - Transformation products:
- not measured
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.003 d-1
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: QSAR estimated value; The substance is within the applicability domain of the model.
- Details on results:
- The hydrolysis of the test item was estimated as very slow. The hydrolysis rate constant was estimated to be 0.00256 1/day.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Using Trend analysis method in OECD QSAR Toolbox v4.2, the hydrolysis rate constant of the test item was estimated to be 0.00256 1/day. The hydrolysis of the test item is classified as very slow.
- Executive summary:
The hydrolysis rate constant was calculated using Trend analysis method as part of OECD QSAR Toolbox. The hydrolysis rate constant of the test item was calculated to be 0.00256 1/days at pH 6.5 - 7.4 (OECD QSAR Toolbox, 2018).
The adequacy of a prediction depends on the following conditions:
a) the (Q)SAR model is scientifically valid: the scientific validity is established according to the OECD principles for (Q)SAR validation;
b) the (Q)SAR model is applicable to the query chemical: a (Q)SAR is applicable if the query chemical falls within the defined applicability domain of the model;
c) the (Q)SAR result is reliable: a valid (Q)SAR that is applied to a chemical falling within its applicability domain provides a reliable result;
d) the (Q)SAR model is relevant for the regulatory purpose.
For assessment and justification of these 4 requirements the QPRF file was developed and attached to this study record.
Assessment of estimation domain
The assessment of the estimation domain was documented in the QSAR Prediction Reporting Format file (QPRF). Please refer to the attached document for the details of the prediction and the assessment of the estimation domain.
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2018-03-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Please refer to the QPRF file provided under the section attached justification.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSAR R.6
- Principles of method if other than guideline:
- Estimation of the Hydrolysis Rate Constant using Trend analysis method in OECD QSAR Toolbox v4.2.
- GLP compliance:
- no
- Specific details on test material used for the study:
- SMILES: C1COCCN1
- Transformation products:
- not measured
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.099 d-1
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: QSAR estimated value; The substance is within the applicability domain of the model.
- Details on results:
- The hydrolysis of the test item was estimated as moderate. The hydrolysis rate constant was estimated to be 0.0992 1/day.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Using Trend analysis method in OECD QSAR Toolbox v4.2, the hydrolysis rate constant of the test item was estimated to be 0.0992 1/day. The hydrolysis of the test item is classified as moderate.
- Executive summary:
The hydrolysis rate constant was calculated using Trend analysis method as part of OECD QSAR Toolbox. The hydrolysis rate constant of the test item was calculated to be 0.0992 1/days at pH 6.5 - 7.4 (OECD QSAR Toolbox, 2018).
The adequacy of a prediction depends on the following conditions:
a) the (Q)SAR model is scientifically valid: the scientific validity is established according to the OECD principles for (Q)SAR validation;
b) the (Q)SAR model is applicable to the query chemical: a (Q)SAR is applicable if the query chemical falls within the defined applicability domain of the model;
c) the (Q)SAR result is reliable: a valid (Q)SAR that is applied to a chemical falling within its applicability domain provides a reliable result;
d) the (Q)SAR model is relevant for the regulatory purpose.
For assessment and justification of these 4 requirements the QPRF file was developed and attached to this study record.
Assessment of estimation domain
The assessment of the estimation domain was documented in the QSAR Prediction Reporting Format file (QPRF). Please refer to the attached document for the details of the prediction and the assessment of the estimation domain.
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2018-03-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Please refer to the QPRF file provided under the section attached justification.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSAR R.6
- Principles of method if other than guideline:
- Estimation of the Hydrolysis Rate Constant using Trend analysis method in OECD QSAR Toolbox v4.2.
- GLP compliance:
- no
- Specific details on test material used for the study:
- SMILES: CCCCCCCCCCCC(=O)O
Lauric acid - Transformation products:
- not measured
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.328 d-1
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: QSAR estimated value; The substance is not completely within the applicability domain of the model.
- Details on results:
- The hydrolysis of the test item was estimated as fast. The hydrolysis rate constant was estimated to be 0.328 1/day.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Using Trend analysis method in OECD QSAR Toolbox v4.2, the hydrolysis rate constant of the test item was estimated to be 0.328 1/day. The hydrolysis of the test item is classified as fast.
- Executive summary:
The hydrolysis rate constant was calculated using Trend analysis method as part of OECD QSAR Toolbox. The hydrolysis rate constant of the test item was calculated to be 0.328 1/days at pH 6.5 - 7.4 (OECD QSAR Toolbox, 2018).
The adequacy of a prediction depends on the following conditions:
a) the (Q)SAR model is scientifically valid: the scientific validity is established according to the OECD principles for (Q)SAR validation;
b) the (Q)SAR model is applicable to the query chemical: a (Q)SAR is applicable if the query chemical falls within the defined applicability domain of the model;
c) the (Q)SAR result is reliable: a valid (Q)SAR that is applied to a chemical falling within its applicability domain provides a reliable result;
d) the (Q)SAR model is relevant for the regulatory purpose.
For assessment and justification of these 4 requirements the QPRF file was developed and attached to this study record.
Assessment of estimation domain
The assessment of the estimation domain was documented in the QSAR Prediction Reporting Format file (QPRF). Please refer to the attached document for the details of the prediction and the assessment of the estimation domain.
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2018-03-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Please refer to the QPRF file provided under the section attached justification.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSAR R.6
- Principles of method if other than guideline:
- Estimation of the Hydrolysis Rate Constant using Trend analysis method in OECD QSAR Toolbox v4.2.
- GLP compliance:
- no
- Specific details on test material used for the study:
- SMILES: CCCCC(CC)COP(=O)(O)OCC(CC)CCCC
bis(2-ethylhexyl) hydrogen phosphate - Transformation products:
- not measured
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.016 d-1
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: QSAR estimated value; The substance is not completely within the applicability domain of the model.
- Details on results:
- The hydrolysis of the test item was estimated as moderate. The hydrolysis rate constant was estimated to be 0.016 1/day.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Using Trend analysis method in OECD QSAR Toolbox v4.2, the hydrolysis rate constant of the test item was estimated to be 0.016 1/day. The hydrolysis of the test item is classified as moderate.
- Executive summary:
The hydrolysis rate constant was calculated using Trend analysis method as part of OECD QSAR Toolbox. The hydrolysis rate constant of the test item was calculated to be 0.016 1/days at pH 6.5 - 7.4 (OECD QSAR Toolbox, 2018).
The adequacy of a prediction depends on the following conditions:
a) the (Q)SAR model is scientifically valid: the scientific validity is established according to the OECD principles for (Q)SAR validation;
b) the (Q)SAR model is applicable to the query chemical: a (Q)SAR is applicable if the query chemical falls within the defined applicability domain of the model;
c) the (Q)SAR result is reliable: a valid (Q)SAR that is applied to a chemical falling within its applicability domain provides a reliable result;
d) the (Q)SAR model is relevant for the regulatory purpose.
For assessment and justification of these 4 requirements the QPRF file was developed and attached to this study record.
Assessment of estimation domain
The assessment of the estimation domain was documented in the QSAR Prediction Reporting Format file (QPRF). Please refer to the attached document for the details of the prediction and the assessment of the estimation domain.
Referenceopen allclose all
To determined the hydrolysis rate constant of the test item, Trend analysis method was used. A calculated log Kow value of 2.65 was used for the estimation. This value is in the applicability domain of the method (from -1.06 to 4.7). For more details of the prediction, please refer to the attached QPRF. A detailed information on the data matrix used for the method can be found in the attached table.
To determined the hydrolysis rate constant of the test item, Trend analysis method was used. A calculated log Kow value of -0.65 was used for the estimation. This value is in the applicability domain of the method (from -1.06 to 4.7). For more details of the prediction, please refer to the attached QPRF. A detailed information on the data matrix used for the method can be found in the attached table.
To determined the hydrolysis rate constant of the test item, Trend analysis method was used. A calculated log Kow value of 5.0 was used for the estimation. This value is in the applicability domain of the method (from -1.06 to 4.7). For more details of the prediction, please refer to the attached QPRF. A detailed information on the data matrix used for the method can be found in the attached table.
To determined the hydrolysis rate constant of the test item, Trend analysis method was used. A calculated log Kow value of 6.07 was used for the estimation. This value is out of the applicability domain of the method (from -1.06 to 4.7). For more details of the prediction, please refer to the attached QPRF. A detailed information on the data matrix used for the method can be found in the attached table.
Description of key information
The test on hydrolysis is not needed.
Key value for chemical safety assessment
Additional information
All constituent of the test item are classified as readily biodegradable according to the Disseminated ECHA Homepage (Morpholine EC 203-815-1/CAS 110-91-8, Lauric acid EC 205-582-1/CAS 143-07-7, bis(2-ethylhexyl) hydrogen phosphate EC 206-056-4/CSA 298-07-7 and 2-ethylhexyl dihydrogen phosphate EC 213-967-0/CAS 1070-03-7). In the ready biodegradability test the multi-constituent substance was determined to be inherently biodegradable. Nevertheless, the test substance is regarded to be biodegradable when evaluating the need for a hydrolysis study. Relevant data from analytical analysis together with QSAR estimations showed that the test item is stable after 96 h in ultrapure water. Based on this information, the test item is considered to be hydrolytically stable, thus, no study on hydrolysis is needed.
During an analytical measurements of the stability of the test item in ultrapure water, it was determined that the test item is stable, based on the content of its constituents, after 96 h storage. The recovery of the test items constituents was between 101 – 104 %. Therefore, no test on hydrolysis is needed.
Additionally, a QSAR prediction of the hydrolysis of the constituents was performed using OECD QSAR Toolbox v4.2 (OECD, 2018). These predictions showed that the main constituents are stable and their hydrolysis will be very slow to moderate. This information supports the fact that the test item is stable in water, thus, no study on hydrolysis is needed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.