Registration Dossier
Registration Dossier
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EC number: 264-439-1 | CAS number: 63741-10-6
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Specific details on test material used for the study:
- The batch of Disperse Brown 27 (4852-1501) tested was a brown powder with a purity of 99.7 %
- Radiolabelling:
- no
- Test temperature:
- 35 °C ± 1 °C
- Details on study design: HPLC method:
- A 1000 mg/L stock solution of the test item was prepared in methanol. In order to dissolve the test item the stock solution was ultrasonicated for 5 minutes. The stock solution was diluted to obtain an end solution of 55/45 (v/v) methanol/buffer pH 7. The final concentration of the test item solution was 10.0 mg/L.
The test item blank solution was 55/45 (v/v) methanol/buffer pH 7.
The reference substance and test item solutions were injected in duplicate. Blank solutions were analysed by single injection. - Key result
- Type:
- Koc
- Value:
- ca. 430 000 dimensionless
- pH:
- 7
- Temp.:
- 35 °C
- Key result
- Type:
- log Koc
- Value:
- > 5.63 dimensionless
- pH:
- 7
- Temp.:
- 35 °C
- Details on results (HPLC method):
- In the chromatogram of the test item solution, one peak with an average retention time of 11.820 minutes was observed. Under the same analytical conditions, the mean retention time of 4,4’-DDT (log Koc = 5.63) was 6.549 minutes. Hence, it was concluded that the log Koc of test item was > 5.63 (Koc >4.3x105).
- Validity criteria fulfilled:
- yes
- Conclusions:
- The HPLC method using soil-adsorption-reference data was applied for the determination of the adsorption coefficient (Koc) of Disperse Brown 27.
The Koc and log Koc values of the test item at pH 7 were: Koc> 4.3 x 105 and logkoc > 5.63 - Executive summary:
The HPLC method using soil-adsorption-reference data was applied for the determination of the adsorption coefficient (Koc) of Disperse Brown 27.
The Koc and log Koc values of the test item at pH 7 were: Koc> 4.3 x 105 and logkoc > 5.63
Reference
Description of key information
The HPLC method using soil-adsorption-reference data was applied for the determination of the adsorption coefficient (Koc) of Disperse Brown 27.
The Koc and log Koc values of the test item at pH 7 were: Koc> 4.3 x 105 and logkoc > 5.63
Key value for chemical safety assessment
- Koc at 20 °C:
- 5.63
Additional information
[LogKoc: 430000.0]
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