Registration Dossier
Registration Dossier
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EC number: 265-805-3 | CAS number: 65520-42-5
Toxicity to reproduction
Administrative data
- Endpoint:
- one-generation reproductive toxicity
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Adipic acid diesters category. See attached report.
Data source
Materials and methods
Test material
- Reference substance name:
- Bis[2-[2-(2-butoxyethoxy)ethoxy]ethyl] adipate
- EC Number:
- 265-807-4
- EC Name:
- Bis[2-[2-(2-butoxyethoxy)ethoxy]ethyl] adipate
- Cas Number:
- 65520-46-9
- Molecular formula:
- C26H50O10
- IUPAC Name:
- bis{2-[2-(2-butoxyethoxy)ethoxy]ethyl} adipate
- Test material form:
- other: liquid
Constituent 1
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 170 mg/kg bw/day
- Basis for effect level:
- body weight and weight gain
- Remarks on result:
- other: worst case among category members
Target system / organ toxicity (P0)
- Critical effects observed:
- no
Results: P1 (second parental generation)
Effect levels (P1)
- Remarks on result:
- not measured/tested
Results: F1 generation
Effect levels (F1)
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 170 mg/kg bw/day
- Basis for effect level:
- body weight and weight gain
- Remarks on result:
- other: worst case among category memebrs
Results: F2 generation
Effect levels (F2)
- Remarks on result:
- not measured/tested
Overall reproductive toxicity
- Key result
- Reproductive effects observed:
- no
- Lowest effective dose / conc.:
- 170 mg/kg bw/day
- Treatment related:
- not specified
Applicant's summary and conclusion
- Conclusions:
- According to the category approach, no effects on reproduction are expected for adipic acid diesters category members. However, the worst case NOAEL available among category memebrs is used for risk assessment purposes.
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