Registration Dossier
Registration Dossier
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EC number: 247-865-2 | CAS number: 26638-53-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP. Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Version / remarks:
- In addition, the procedures were designed to meet the test methods prescribed by the following guidelines and guidance document:
• Commission regulation (EC) No. 440/2008 of 30 May 2008, Part C: Methods for the determination of ecotoxicity, Publication No. L142, C3: “Algal Inhibition Test”; Amended by EC No. 761/2009 of 23 July 2009, Publication No. L220.
• ISO International Standard 8692: "Water quality - Freshwater algal growth inhibition test with unicellular green algae", Second edition, 01 October 2004.
• Guidance document on aquatic toxicity testing of difficult substances and mixtures, OECD series on testing and assessment number 23, December 14, 2000. - Deviations:
- no
- GLP compliance:
- yes
Test material
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Effect concentrations
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.16 mg/L
- Basis for effect:
- growth rate
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the present study with Pseudokirchneriella subcapitata, no reduction of growth rate or inhibition of yield was recorded at any of the concentrations of 1574 CETONA tested.
The EC50 for growth rate reduction (72h-ERC50) and the EC50 for yield inhibition (72h-EYC50) was beyond the range tested, i.e. exceeded a TWA concentration of 0.16 mg/l being the highest soluble concentration in medium.
The 72h-NOEC for both growth rate reduction and yield inhibition was 0.16 mg/l.
Due to the very low solubility of 1574 CETONA in water, concentration levels that might be toxic for algae could not be reached.
The EC50 for yield inhibition (EyC50:0-72h) was 9.8 mg/l with a 95% confidence interval ranging from 5.7 to 17 mg/l.
The NOEC for growth rate reduction was 3.2 mg/l. The NOEC for yield inhibition was 1.0 mg/l.
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