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EC number: 240-387-5 | CAS number: 16298-03-6
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 February 2013 - 26 April 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- (2009)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- (2006)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Version / remarks:
- (1996)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- other: Effusion method: Isothermal thermogravimetry
Test material
- Reference substance name:
- Methyl 3-aminopyrazinecarboxylate
- EC Number:
- 240-387-5
- EC Name:
- Methyl 3-aminopyrazinecarboxylate
- Cas Number:
- 16298-03-6
- Molecular formula:
- C6H7N3O2
- IUPAC Name:
- methyl 3-aminopyrazine-2-carboxylate
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): Amiloride Compound 6
- Description: Tan powder
- Storage condition of test material: In refrigerator (2-8°C) protected from light, desiccated
- Other: Reactive to light, moisture and oxygen
Constituent 1
Results and discussion
Vapour pressureopen allclose all
- Temp.:
- 25 °C
- Vapour pressure:
- 9.3 other: E-03 Pa
- Temp.:
- 20 °C
- Vapour pressure:
- 4.6 other: E-03 Pa
Any other information on results incl. tables
Results of the isothermal TGA analysis
Temperature [°C] |
Weight loss [µg/min] |
νT [g/cm2/h] |
logνT |
logPT |
100 |
20.57 |
2.46E-03 |
-2.61 |
1.57 |
17.69 |
2.11E-03 |
-2.68 |
1.50 |
|
110 |
47.07 |
5.62E-03 |
-2.25 |
1.95 |
45.06 |
5.38E-03 |
-2.27 |
1.93 |
|
120 |
99.71 |
1.19E-02 |
-1.92 |
2.29 |
96.63 |
1.15E-02 |
-1.94 |
2.28 |
|
130 |
196.8 |
2.35E-02 |
-1.63 |
2.60 |
191.7 |
2.29E-02 |
-1.64 |
2.59 |
Vapour pressure regression curve: log PT = -5311 x 1/T + 15.78 (r = 0.998, n= 8).
Log PT 20°C was calculated to be -2.33
Log PT 25°C ws calculated to be -2.03
Applicant's summary and conclusion
- Conclusions:
- The vapour pressure of Amiloride Compound 6 was determined to be 9.3E-03 Pa at 25°C (4.6E-03 Pa at 20°C) using the isothermal thermogravimetric effusion method (GLP-compliant study in accordance with EC A.4, OECD 104 and EPA OPPTS 830.7950).
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