Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-447-4 | CAS number: 121-05-1
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish:
Experimental data on the toxicity of 2-aminoethyldiisopropylamine (CAS 121-05-1) to fish are not available. Regarding the tonnage band (1 -1000 t/a, intermediate) a study on the short-term toxicity to fish is not required. In order to assess the toxicity to fish, (Q)SAR models were used. The estimated data indicate that acute toxicity to fish is not to be expected as all 96-h LC50 values are > 100 mg/L.
Based on a weight-of-evidence approach by the available calculated data 2-aminoethyldiisopropylamine (CAS 121-05-1) is assessed to be with high probability acutely not harmful to fish.
Short-term toxicity to aquatic invertebrates:
For the assessment of the acute toxicity of2-aminoethyldiisopropylamine(CAS 121-05-1) to aquatic invertebrates there are data from a static GLP-guideline study according to OECD 202 available, using Daphnia magna as test organism. Based onpH-adjusted test solutions, the 48-h EC50 was determined to be >100 mg/L (nominal).
2 -aminoethyldiisopropylamine is concluded to be acutely not harmful to aquatic invertebrates.
Toxicity to aquatic algae and cyanobacteria:
The assessment of the toxicity of 2-aminoethyldiisopropylamine (CAS 121-05-1) to aquatic algae and cyanobacteria is based on a read-across approach to the structurally analogous substance ethyldiisopropylamine (CAS 7087-68-5).
A study on growth inhibition of the freshwater algae Pseudokirchneriella subcapitata, exposed to the analogue ethyldiisopropylamine (CAS 7087-68-5) for 72h, was performed according to OECD TG 201. The pH of the stock solution was adjusted to 8 in order to limit the pH increase during the test. Based on measured test concentrations the 72-h ErC50 was determined to be 150 mg/L (72-h ErC10 = 52 mg/L).
Based on the available read-across data, 2-aminoethyldiisopropylamine is assessed to be with high probability acutely not harmful to aquatic algae and cyanobacteria.
Toxicity to microorganisms:
The toxicity of 2-aminoethyldiisopropylamine (CAS 121-05-1) to aquatic microorganisms was investigated in a short-term respiration inhibition test conducted according to ISO 8192 (BASF AG, 1990; report no.: 2-1026-35/89a), using domestic activated sludge as inoculum. Respiration was measured after 30 minutes and 180 minutes. The 30-min EC20 was determined to be > 1000mg/L based on nominal test concentrations (180-min EC20 >1000mg/L).
In addition, there are supporting data from a further short-term respiration inhibition test available; the study was conducted similarly to OECD TG 209 (BASF AG, 1989). A 30-min EC20 was determined to be ≥ 659 mg/L based on nominal test concentrations. As inoculum, domestic activated sludge was used.
Based on the available data it can be concluded for 2-aminoethyldiisopropylamine (CAS 121-05-1) that inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
