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EC number: 204-447-4 | CAS number: 121-05-1
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Not readily biodegradable (according to OECD criteria).
Key value for chemical safety assessment
Additional information
The ready biodegradability of 2 -aminoethyldiisopropylamine (CAS 121-05-1) was studied according to ISO 7827, which is equivalent or similar to OECD E (BASF AG, 1989; report no. 01.89/0413/01). The inoculum was effluent from a wastewater treatment plant treating predominantly domestic sewage. After 28 d, the DOC removal reached 11%. Therefore, the substance is not readily biodegradable.
The inherent degradability was investigated in a Zahn-Wellens test according to OECD 302B using activated sludge from a wwtp treating predominantly domestic sewage (BASF AG, 1989; report no. 01/89/0431/01). The DOC removal reached 13% after 28 d. Therefore, the substance is not inherently biodegradable, but poorly eliminated from water.
In addition, the biodegradation was estimated using several estimation models, supporting the poor elimination potential of the substance:
- BIOWIN v4.10, EPI Suite v4.11:
According to the overall ready biodegradability prediction of BIOWIN, which is based on BIOWIN 3 and 5, the substance is not readily biodegradable. Only BIOWIN1 indicated a fast biodegradation, while the other models (BIOWIN 2 - 6) resulted in "does not biodegrade fast" or longer timeframe for ultimate/primary degradation. The substance is within the applicability domain of the model. According to REACH Guidance document R.7b, the calculated probability values can be used as cut-off points between ready and not-ready biodegradability. Following this approach, again only BIOWIN 1 predicts the substance to be readily biodegradable, while the majority of the models supports the non-ready biodegradability of the substance.
- Catalogic v5.11.19, CATALOGIC Kinetic 301B v.02.09:
The model predicted the substance to be not readily biodegradable. Based on CO2-evolution, the model estimated 0% biodegradation after 28 days; the primary half-life was calculated to be 4 months and 26 days. The ultimate half-life was predicted to be 2 years, 2 months and 25 d. The substance is not within the applicability domain of the model (100% parameter domain; 100% mechanistic domain; 70% structural domain due to unknown fragments).
- Catalogic v5.11.19, CATALOGIC 301C v09.13:
The model predicted the substance to be not readily biodegradable. Based on BOD, the model estimated 49% biodegradation after 28 days; the primary half-life was calculated to be 15 days. The ultimate half-life was 28 days. The substance is not within the applicability domain of the model (100% parameter domain; 100% mechanistic domain; 70% structural domain due to unknown fragments).
- Catalogic v5.11.19, CATALOGIC Kinetic 301F v13.16:
The model predicted the substance to be not readily biodegradable. Based on BOD, the model estimated 1% biodegradation after 28 days; the primary half-life was calculated to be 4 months and 26 days. The ultimate half-life was 4 years, 10 months, 22 days. The substance is not within the applicability domain of the model (100% parameter domain; 100% structural domain; 0% metabolic domain). The simulator of metabolism failed to simulate the mineralization.
Based on weight-of-evidence approach, it can be concluded that the substance is not readily biodegradable according to OECD criteria, but poorly degradable.
Overview table:
Source |
Biodegradability |
In AD |
Remarks |
BASF AG (1990), report no. 01.89/0413/01: ISO 7827 (similar to OECD 301E) |
11% (DOC removal) in 28 d: not readily biodegradable |
- |
Inoculum: effluent of municipal WWTP |
BASF AG (1989), report no. 01.89/0413/01: OECD 302B |
13% (DOC removal) in 28 d: not inherently biodegradable |
- |
Inoculum: activated sludge of municipal WWTP |
BIOWIN v4.10 (EPI Suite v4.11) |
Overall ready biodegradability prediction: No |
Yes |
Prediction based on BIOWIN 3 and 5 |
BIOWIN1: Biodegrades fast (0.65) |
Yes |
Probability cut-off point between ready and non-ready biodegradability acc. to R.7.9.41 (REACH Guidance R.7b, v4.0, June 2017): 0.5 |
|
BIOWIN2: Does not biodegrade fast (0.46) |
Yes |
Probability cut-off point: 0.5 |
|
BIOWIN3: Weeks-months (2.65) |
Yes |
Probability cut-off point: 2.75 |
|
BIOWIN5: Does not biodegrade fast (0.23) |
Yes |
Probability cut-off point: 0.5 |
|
BIOWIN6: Does not biodegrade fast (0.12) |
Yes |
Probability cut-off point: 0.5 |
|
OASIS Catalogic v5.11.19 – Kinetic 301B v2.09 |
0% (CO2 evolution); not readily biodegradable |
No |
Out of structural domain |
OASIS Catalogic v5.11.19 – 301C v9.13 |
49%; not readily biodegradable |
No |
Out of structural domain |
OASIS Catalogic v5.11.19 – Kinetic 301F v13.16 |
1%; not readily biodegradable |
No |
Out of metabolic domain: The simulator of metabolism failed to simulate the mineralization. |
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