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EC number: 212-985-6 | CAS number: 901-44-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- Adaptation with the slow-stirring method described in the OECD 123 guideline
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 111.8 mg/L
- Conc. based on:
- act. ingr.
- Loading of aqueous phase:
- 3 g/L
- Incubation duration:
- 4 d
- Temp.:
- 20.4 °C
- pH:
- 5
- Details on results:
- Sample filtration or centrifugation followed or not by fitration did not yield different results in term of measured concentrations. Therefore, the three sample preparation methods were considered equivalent. The data obtained from filtered samples were used to determine the water solubility of the test item.
The test concentrations reached a plateau at around 112 mg/L in filtered samples after 72-hour stirring. Based on OECD test guideline 105 specification, the saturation equilibrium was considered to be reached from 48 hours. Indeed, the concentrations measured in at least the four last sampling points (24, 48, 72 and 96 h) did not differ by more than 15% during this period. The water solubility of the test item was therefore calculated as the mean of the concentrations determined during this period. The solubility of the test item in water is 111.8 mg/L. - Conclusions:
- Water solubility of 2,2'-isopropylidenebis(p-phenyleneoxy)diethanol is 111.8 mg/L.
- Executive summary:
The OECD test guideline 105 for the Testing of Chemicals (Water solubility) served as a basis for the procedure. According to the first results obtained and as the test item was a viscous liquid, the definitive test protocol was adapted from the flask method under slow stirring conditions as described in the OECD test guideline 123. Special temperature controlled glass-jacketed test vessels described in the OECD test guideline 123 with a sampling tap at the lower end and a magnetic stir bar at their bottom were used. Three flasks were used for the test (1 control flask and 2 replicate flasks). The preparation was made at 3 g/L. The solution were continuously stirred throughout the test period with the magnetic stir bar so as to create a vortex depth of around 0.5 cm. Over the test period, test samples were taken from the flasks after a 10 min cooling period at 24, 48, 72 and 96 hours. Samples were repeatedly sampled from the same flasks over time. Each sample was divided into 3 aliquots: one was not processed, one was filtered (through 0.8 µm then 0.2 µm filters) and one was centrifuged (2000 g, 10 min). These protocols were applied to avoid undissolved particles or droplets in the samples taken for analysis. However, for the last sampling time (96 hour), only filtered aliquot was analysed as no significant difference between processing methods was observed at the three previous sampling times (i.e., the slow-stirring very probably allowed avoiding the presence of particles or droplets in the samples). Based on OECD test guideline 105 specification, the saturation equilibrium was considered to be reached from 48 hours. Indeed, the concentrations measured in at least the four last sampling points (24, 48, 72 and 96 h) did not differ by more than 15% during this period. The water solubility of the test item was therefore calculated as the mean of the concentrations determined during this period. The solubility of the test item in water is 111.8 mg/L.
Reference
Table 1: concentration of test item in the successive samples in the control flask and the two replicate flasks. Three sample processing were used. They did not yield different results and were thus considered equivalent. Measures were done in triplicate for each sample.
Sampling time |
Flask |
Sample treatment |
Test item concentration(mg/L) |
||||
Measure 1 |
Measure 2 |
Measure 3 |
Mean |
RSD (%) |
|||
24h |
Control |
Raw sample |
<DL |
<DL |
ND |
NA |
NA |
Replicate 1 |
Raw sample |
98.5 |
107.0 |
101.4 |
102.3 |
4.2 |
|
Filtered |
96.9 |
113.0 |
116.6 |
108.8 |
9.7 |
||
Centrifuged |
103.0 |
102.1 |
104.7 |
103.3 |
1.3 |
||
Replicate 2 |
Raw sample |
99.2 |
99.9 |
102.1 |
100.4 |
1.5 |
|
Filtered |
109.2 |
114.9 |
105.2 |
109.7 |
4.4 |
||
Centrifuged |
90.4 |
86.6 |
90.8 |
89.3 |
2.6 |
||
48h |
Control |
Raw sample |
<DL |
<DL |
ND |
NA |
NA |
Replicate 1 |
Raw sample |
112.0 |
114.1 |
113.1 |
113.1 |
0.9 |
|
Filtered |
114.7 |
116.6 |
115.7 |
115.7 |
0.8 |
||
Centrifuged |
107.0 |
106.9 |
113.7 |
109.2 |
3.6 |
||
Replicate 2 |
Raw sample |
110.5 |
117.2 |
113.8 |
113.8 |
2.9 |
|
Filtered |
109.1 |
116.9 |
118.2 |
114.8 |
4.3 |
||
Centrifuged |
106.7 |
107.0 |
101.5 |
105.1 |
2.9 |
||
72h |
Control |
Raw sample |
<DL |
<DL |
ND |
NA |
NA |
Replicate 1 |
Raw sample |
115.6 |
123.3 |
120.5 |
119.8 |
3.3 |
|
Filtered |
118.1 |
120.0 |
115.3 |
117.8 |
2.0 |
||
Centrifuged |
114.4 |
109.1 |
107.1 |
110.2 |
3.4 |
||
Replicate 2 |
Raw sample |
114.5 |
112.6 |
113.6 |
113.6 |
0.9 |
|
Filtered |
115.8 |
118.5 |
112.0 |
115.4 |
2.8 |
||
Centrifuged |
107.2 |
110.4 |
113.6 |
110.4 |
2.9 |
||
96h |
Control |
Raw sample |
<DL |
<DL |
ND |
NA |
NA |
Replicate 1 |
Filtered |
118.5 |
119.1 |
117.2 |
118.3 |
0.8 |
|
Replicate 2 |
Filtered |
112.8 |
113.9 |
112.2 |
113.0 |
0.8 |
Description of key information
The OECD test guideline 105 for the Testing of Chemicals (Water solubility) served as a basis for the procedure. According to the first results obtained and as the test item was a viscous liquid, the definitive test protocol was adapted from the flask method under slow stirring conditions as described in the OECD test guideline 123. Special temperature controlled glass-jacketed test vessels described in the OECD test guideline 123 with a sampling tap at the lower end and a magnetic stir bar at their bottom were used. Three flasks were used for the test (1 control flask and 2 replicate flasks). The preparation was made at 3 g/L. The solution were continuously stirred throughout the test period with the magnetic stir bar so as to create a vortex depth of around 0.5 cm. Over the test period, test samples were taken from the flasks after a 10 min cooling period at 24, 48, 72 and 96 hours. Samples were repeatedly sampled from the same flasks over time. Each sample was divided into 3 aliquots: one was not processed, one was filtered (through 0.8 µm then 0.2 µm filters) and one was centrifuged (2000 g, 10 min). These protocols were applied to avoid undissolved particles or droplets in the samples taken for analysis. However, for the last sampling time (96 hour), only filtered aliquot was analysed as no significant difference between processing methods was observed at the three previous sampling times (i.e., the slow-stirring very probably allowed avoiding the presence of particles or droplets in the samples). Based on OECD test guideline 105 specification, the saturation equilibrium was considered to be reached from 48 hours. Indeed, the concentrations measured in at least the four last sampling points (24, 48, 72 and 96 h) did not differ by more than 15% during this period. The water solubility of the test item was therefore calculated as the mean of the concentrations determined during this period. The solubility of the test item in water is 111.8 mg/L.
Key value for chemical safety assessment
- Water solubility:
- 111.8 mg/L
Additional information
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