Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-112-3 | CAS number: 13170-23-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study did not meet current guideline requirements for eye irritation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Diacetoxydi-tert-butoxysilane
- EC Number:
- 236-112-3
- EC Name:
- Diacetoxydi-tert-butoxysilane
- Cas Number:
- 13170-23-5
- Molecular formula:
- C12H24O6Si
- IUPAC Name:
- (acetyloxy)bis(tert-butoxy)silyl acetate
- Test material form:
- not specified
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- other: Vehicle not mentioned therefore assumed to be undiluted.
- Controls:
- not required
- Duration of treatment / exposure:
- No data
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Scoring not according to current guidelines
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: The authors concluded that the test substance causes moderate irritation to the eyes of rabbits.
Any other information on results incl. tables
Both rabbits showed some reversible corneal opacity and slight effects on the iris. Conjunctival redness was not completely reversible after 7 days in one of the rabbits. Observed conjunctival swelling was reversible in both rabbits by day 3. No ulceration was observed.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- In a limited eye irritation study (reliability score 4) dibutoxy(dimethyl)silane was concluded to be moderately irritating to the eyes of rabbits.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
