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EC number: 203-918-1 | CAS number: 111-88-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981-01-12 to 1982-01-19
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was classified as reliable with restrictions because it was conducted in accordance to GLP, was reviewed by Quality Assurance and followed a protocol similar to OECD guideline 404.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Animals were tested under occlusive conditions and exposure period was 24 hours
- GLP compliance:
- yes
Test material
- Reference substance name:
- Octane-1-thiol (CAS # 111-88-6)
- IUPAC Name:
- Octane-1-thiol (CAS # 111-88-6)
- Details on test material:
- - Name of test material (as cited in study report): n-Octyl Mercaptan
- Substance type: Heavy Mercaptan
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: University of Utah Vivarium
- Housing: housed individually in galvanized steel rabbit cage with screen floors and pans
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +/- 3
- Humidity (%): 30 to 60
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: From: 1981-01-06 To: 1981-01-19
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 7 days
- Number of animals:
- 6 New Zealand albino rabbits
- Details on study design:
- TEST SITE
- Type of wrap if used: gauze patch secured with non adhesive tape and covered with plastic tube
REMOVAL OF TEST SUBSTANCE
- Washing (if done): lightly sponged
- Time after start of exposure: 7 days
SCORING SYSTEM: Draize technique
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks:
- Draize score
- Basis:
- mean
- Time point:
- other: 25 and 72 hours
- Score:
- ca. 0.5
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- The Phillips octane-1-thiol sample elicited very slight erythema on both abraded and unabraded sites in 2 animals at 25 hours post dosing. One animal had slight erythema on the abraded site only. The other 3 animals appeared normal. At 72 hours post dosing, 2 animals had very slight erythema on both the abraded and unabraded sites. All other animals had either returned to normal or remained normal. On day 7, erythema and/or edema was not observed on any animal all appeared animals, except for one animal (#612) which had a very slight induration.
Any other information on results incl. tables
Animal Number |
624 |
647 |
626 |
611 |
612 |
613 |
Ave. |
Range |
Observation, prescreen |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
25 hour |
0 |
1.0 |
0.5 |
1.0 |
0 |
0 |
0.4 |
0-1 |
72 hour |
0 |
0 |
1.0 |
2.0 |
0 |
0 |
0.5 |
0-2 |
7 day |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Combined 25 & 72 hour |
0 |
0.5 |
0.8 |
1.5 |
0 |
0 |
0.5 |
0-1.5 |
Combined 25 & 72 hour and 7 day |
0 |
0.3 |
0.5 |
1.0 |
0 |
0 |
0.3 |
0-1.0 |
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information (Not classified) Criteria used for interpretation of results: EU
- Conclusions:
- Octane-1-thiol demonstrated a slight irritance in 3 out of 6 rabbits using the Primary Skin Irritation Test. The mean Draize score of 0.3 (7 days) was tabulated from the 6 rabbits at 3 observation periods.
- Executive summary:
In a primary dermal irritation study, 6 young adult New Zealand albino rabbits were dermally exposed to 0.5 mL of octance-1-thiol for 24 hours to 1 square inch of abraded skin. Animals then were observed for 7 days. Irritation was scored by the method of Draize primary skin irritation test.
The Phillips octane-1-thiol sample elicited very slight erythema on both abraded and unabraded sites in 2 animals at 25 hours past dosing. One animal had slight erythema on the abraded site only. The other 3 animals appeared normal. At 72 hours past dosing, 2 animals had very slight erythema on both the abraded and unabraded sites. All other animals had either returned to normal or remained normal. On day 7, erythema and/or edema was not observed on any animal all appeared animals, except for animal 612 which had a very slight induration. In this study, octane-1 -thiol is slightly irritating to the skin based on the Draize primary skin irritation test.
This study was classified as reliable with restrictions because it was conducted in accordance to GLP, was reviewed by Quality Assurance and followed a protocol similar to OECD guideline 404.
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