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EC number: 203-918-1 | CAS number: 111-88-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981-01-05 to 1981-01-27
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was classified as reliable with restrictions because it was well-documented and followed OECD Guideline 402 with some exceptions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- occlusive wrapping used; only one exposure dose was used and it was below the recommended limit dose
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Octane-1-thiol (CAS # 111-88-6)
- IUPAC Name:
- Octane-1-thiol (CAS # 111-88-6)
- Details on test material:
- - Name of test material (as cited in study report): Phillips n-octyl mercaptan (Octane-1-thiol)
- Substance type: Heavy Mercaptan
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: University of Utah Vivarium
- Age at study initiation: young adult
- Weight at study initiation: 2 to 3 Kg
- Housing: Individually in galvanized or stainless steel cages with screen floors
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 70°F ± 3°F
- Humidity (%): 30% to 60%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 1981-01-05 To: 1981-01-27
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: sidesection
- Type of wrap if used: occlusive plastic sheet
REMOVAL OF TEST SUBSTANCE
- Washing (if done): excess sopnged off lightly
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 mL/Kg or 2 g moistened in saline (if solid) - Duration of exposure:
- 24 hours
- Doses:
- 2 ml/kg (1680 mg/kg)
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Twice daily for first 3 days and then daily thereafter; Body weight - prior to dosing and on days 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 680 mg/kg bw
- Remarks on result:
- other: 1680 mg/kg = 2 mL/kg
- Mortality:
- No mortality was observed in either male or female rabbits through the study period.
- Clinical signs:
- other: All animals exhibited erythema, five of six rabbits also developed induration and did not return to normal.
- Gross pathology:
- All tissues appeared normal at necroscopy.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information mortality was not noted but the dose level was below the recommended dose for a limit test Criteria used for interpretation of results: EU
- Conclusions:
- In an acute dermal toxicity study, groups of New Zealand albino rabbits (3/sex) were dermally exposed to octane-1-thiol for 24 hours at a dose of 1680 mg/kg bw. Animals then were observed for 14 days. The dermal LD50 was determined to be >1680 mg/kg bw in males and females.
- Executive summary:
In an acute dermal toxicity study, groups of New Zealand albino rabbits (3/sex) were dermally exposed to octane-1-thiol for 24 hours at a dose of 1680 mg/kg bw. Animals then were observed for 14 days.
No mortality occurred. No treatment related clinical signs, necropsy findings, or body weight. The dermal LD50 was determined to be >1680 mg/kg bw in males and females.
This study was classified as a supporting study because of the dose selection. This study received a Klimisch score of 2 and was classified as reliable with restrictions because it was well-documented and followed OECD Guideline 402 with some exceptions.
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