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EC number: 203-406-8 | CAS number: 106-52-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin sensitization:
The
substance 4-Piperidinol, 1-methyl- is estimated to be not sensitising to
skin of guinea pigs.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from (Q)SAR toolbox version 3.4 and the supporting QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: Prediction is done using QSAR Toolbox version 3.4
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.4
- GLP compliance:
- no
- Justification for non-LLNA method:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 4-Piperidinol, 1-methyl-
- Molecular formula: C6H13NO
- Molecular weight: 115.175 g/mol
- Smiles: C1N(CCC(C1)O)C
- InChl): 1S/C6H13NO/c1-7-4-2-6(8)3-5-7/h6,8H,2-5H2,1H3
- Substance type: organic
- Physical state: liquid - Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- not specified
- Route:
- other: not specified
- Vehicle:
- not specified
- Adequacy of induction:
- not specified
- No. of animals per dose:
- not specified
- Details on study design:
- not specified
- Challenge controls:
- not specified
- Positive control substance(s):
- not specified
- Vehicle:
- not specified
- Reading:
- 1st reading
- Group:
- test chemical
- No. with + reactions:
- 0
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance 4-Piperidinol, 1-methyl- is estimated to be not sensitising to skin of guinea pigs.
- Executive summary:
The skin sensitisation potential for 4-Piperidinol, 1-methyl- is estimated using OECD QSAR toolbox version 3.4. The test substance 4-Piperidinol, 1-methyl- is estimated to be not sensitizing to skin of guinea pigs.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitization
The skin sensitization effects were reported by OECD QSAR toolbox v 3.4 for target substance 4-Piperidinol, 1-methyl-(CAS No: 106-52-5) in guinea pigs. It was observed that the chemical did not produce any skin sensitization reaction. Hence the test chemical 4-Piperidinol, 1-methyl-(CAS No: 106-52-5) can be considered as not sensitizing to guinea pigs.
Another sensitization study was reported by EUROPEAN COMMISSION – European Chemicals Bureau (IUCLID Dataset) in 2016 for similar read across substances N-Methyldiethanolamine (CAS No: 105-59-9) in guinea pigs. This study was carried out in 20 guinea pigs by guinea pig maximization test. During induction, animals were first induced intradermal with 5% test material in propylene glycol and dermally with 100%. Following induction challenge was performed .Since results at Challenge were equivocal, a Re–Challenge was performed in the same manner as the Challenge, but at concentrations of 50% and 10% N–methyldiethanolamine. In order to differentiate dermal reactions produced by irritation from those produced by sensitization, 20 animals (5/sex/Challenge; treated concurrently during Induction with only vehicle or FCA/water emulsion) were subjected to the same Challenge or Re Challenge procedures as the animals which received test material during the Induction exposures. Fourteen days after the last induction exposure, the Challenge treatment was administered topically at 100%. Eighteen of the 20 animals challenged with 100% N–methyldiethanolamine exhibited clear dermal responses. Index of Sensitization at Challenge to N–methyldiethanolamine was 90%. The Severity Indices at Challenge for the test material group at 24 and 48 hours are 0.8 and 1.8, respectively, compared to 0.8 and 1.6, respectively, for the irritation control group (out of a maximum Index of 3.0).Due to the responses seen in the irritation controls, a Re–Challenge was performed at lower, less irritating concentrations. Animals were re–challenged with both 50% and 10% N–methyldiethanolamine at separate sites. Dermal evaluations were made approximately 24 and 48 hours after the removal of Challenge/Re–Challenge patches. It was observed that the test animals treated with re-challenged dose 50% and 10% N–methyldiethanolamine were free of dermal responses. The Severity indices at Re–Challenge at 24 and 48 hours were both 0.0 for both the test group and the irritation control group. Hence the N-Methyldiethanolamine (CAS No: 105-59-9) can be considered as non-sensitizing to guinea pigs at 50% and 10% concentration.
Inventory Multitiered Assessment and Prioritisation (IMAP) NICNAS in 2016 given a report in which skin sensitization efficacy were observed for another similar read across substance Deanol (CAS No: 108010) in guinea pigs at two different concentrations. These studies were conducted in 1988 (REACH, 2012).In the first study Guinea pigs were treated epicutaneously with an occlusive (closed) dressing with a 6 % solution of the chemical in water for six hours per exposure over a period of 3.5 week (10 applications at 6 % over a 3.5 week induction period).
In next study Guinea pigs were intradermally challenged with a 5 % solution of the chemical in ethanol or water. This was followed after 14 days by epicutaneous induction with a 5 % solution of the chemical. All positive control animals (challenged with 0.1 % of DNBC) showed clear effects.
This substance failed to produce clear skin responses of sensitization at both the concentrations (5% and 6%). Hence Deanol (CAS No: 108010) can be considered as non-sensitizing to guinea pigs.
Therefore based upon the available data for target substance as well as for read across substance and applying weight of evidence approach, the test chemical 4-Piperidinol, 1-methyl-(CAS No: 106-52-5) can be classified as non skin sensitizer.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The skin sensitization potential of test chemical 4-Piperidinol, 1-methyl-(CAS No: 106-52-5) was observed in various studies. From the results obtained from these studies it is concluded that the chemical 4-Piperidinol, 1-methyl-(CAS No: 106-52-5) is unable to cause skin sensitization and can be classified as non-sensitizing
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