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EC number: 203-406-8 | CAS number: 106-52-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Adsorption/
desorption:
The
Adsorption Coefficient of test substance 1-methylpiperidin-4-ol (CAS No.
106-52-5) was determined as per the HPLC method (OECD Guideline-121).
The Log Koc value was found to be 1.5212 ± 0.009 at 25°C.
Additional information
Adsorption/
desorption:
Experimental
and Predicted data of adsorption endpoint for the target chemical
1-methylpiperidin-4-ol (Cas no. 106-52-5) and its read across chemical
were reviewed to summarize as follows:
The adsorption coefficient Koc in soil and in sewage sludge 1-methylpiperidin-4-ol(CAS No.106-52-5) was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals. The reference substances were chosen according to functional similarity with the test substance and calibration graph prepared. The reference substances were 4-chloroaniline 4-methylaniline(p-Tolouidine), N-methylaniline, p-toluamide,, Aniline, 2,5-Dichloroaniline, 4-nitrophenol, 2 - nitrophenol, 2-nitrobenzamide, 3-nitrobenzamide, Nitrobenzene, 4-Nitrobenzamide, 1-naphthylamine, 1-naphtol, Direct Red 81, Benzoic acid methylester, Carbendazim, Benzoic acid phenylester, Xylene, Ethylbenzene, Toluene, Naphthalene, 1,2,3-trichlorobenzene, Pentachlorophenol, Phenol, N,N-dimethylbenzamide, 3,5 - dinitrobenzamide, N-methylbenzamide, Benzamide, phenantrene, Acetanilide having Koc value ranging from 1.25 to 4.09. The Log Koc value was determined to be 1.5212 ± 0.009 at 25°C. This log Koc value indicates that the substance 1-methylpiperidin-4-ol has a low sorption to soil and sediment and therefore has moderate migration potential to ground water.
From predicted model EPI suite 2016 indicate that the soil adsorption coefficient (Koc) value of chemical 1-methylpiperidin-4-ol is estimated to be 4.152 L/kg (log KOC = 0.6182) by means of MCI method at 25 deg.C, indicating that it is has a Negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.
Whereas from chemspider predicted database the soil adsorption coefficient i.e Koc value of test substance 1-methylpiperidin-4-ol was estimated to be 2.92 L/Kg i.e Log Koc= 0.4653 at pH 7.4. This Koc value indicates that the substance 1-methylpiperidin-4-ol has a Negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.
And read across Quinuclidin-3-ol (Cas no. 1619-34-7)experimental study from HSDB authorative database indicate that the adsorption coefficient (Koc) of substance 3-quinuclidinol was found to be 8 L/kg (log Koc 0.903) using a structure estimation method based on molecular connectivity indices.This Koc value suggests that 3-quinuclidinol is expected to have very high mobility in soil.
From same source i.e HSDB database the adsorption coefficient (Koc) of read across substance N-methyldiethanolamine (Cas no. 105-59-9) was found to be 1 L/kg (log koc 0) using a structure estimation method based on molecular connectivity indices. This Koc value suggests that N-methyldiethanolamine is expected to have very high mobility in soil.
Thus based on the above all studies it is concluded that the test substance 1-methylpiperidin-4-ol (Cas no. 106-52-5) has a Negligible to slow sorption to soil and sediment i.e have high to moderate mobility to soil/ sediment.
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