Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2004-06-07 - 2004-07-19
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report date:
2005

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
27 July 1995.
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
Flucytosine
EC Number:
217-968-7
EC Name:
Flucytosine
Cas Number:
2022-85-7
Molecular formula:
C4H4FN3O
IUPAC Name:
flucytosine
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
please refer to Test material information

Results and discussion

Melting / freezing point
Key result
Decomposition:
yes
Decomp. temp.:
>= 569 - <= 571 K

Any other information on results incl. tables

Similar thermographic profiles were obtained using air and nitrogen atmospheres; this indicates that the observed decomposition in the determinations is probably thermal and not oxidative.

Applicant's summary and conclusion

Conclusions:
The test material has been determined to decompose at approximately 569 to 571 K (295.5 to 298 °C), prior to melting.