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EC number: 284-915-2 | CAS number: 84989-26-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From February 11 to 14, 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Chromate(3-), [3-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-2-hydroxy-5-nitrobenzenesulfonato(3-)][3-hydroxy-4-[(2-hydroxy-1-naphthalenyl)azo]-7-nitro-1-naphthalenesulfonato(3-)]-, sodium
- EC Number:
- 284-915-2
- EC Name:
- Chromate(3-), [3-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-2-hydroxy-5-nitrobenzenesulfonato(3-)][3-hydroxy-4-[(2-hydroxy-1-naphthalenyl)azo]-7-nitro-1-naphthalenesulfonato(3-)]-, sodium
- Cas Number:
- 84989-26-4
- Molecular formula:
- C36H20CrN8Na3O14S2
- IUPAC Name:
- trisodium 12'-methyl-6',7-dinitro-14'-phenyl-2',13,15,16'-tetraoxa-1λ⁵,2,9',10'λ⁵,13',14'-hexaaza-14-chromaspiro[hexacyclo[12.11.0.0³,¹².0⁴,⁹.0¹⁶,²⁵.0¹⁹,²⁴]pentacosane-14,1'-tetracyclo[8.6.0.0³,⁸.0¹¹,¹⁵]hexadecane]-1,3,3'(8'),4',5,6',7,9,9',11,11'(15'),12',16(25),17,19,21,23-heptadecaene-1,10'-bis(ylium)-14,14,14-triuide-4',10-disulfonate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoerin AG CH 4414 Fuellinsdorf / Switzerland.
- Age at study initiation: 15 - 16 weeks
- Weight at study initiation: 2.1 - 2.8 kg
- Housing: individually in stainless steel cages equipped with an automatic cleaning, and drinking system.
- Diet: ad libitum; pelleted standard Kliba 341, Batch 11/85 rabbit maintenance diet. Food was analysed for contaminants.
- Water: ad libitum; community tap water from Itingen. Water was analysed for contaminants.
- Acclimation period: four days under laboratory conditions after veterinary examination.
ENVIRONMENTAL CONDITIONS
- Temperature: 22 ± 3 °C.
- Humidity: 40 - 70 %.
- Air changes: air-conditioned with 10-15 air changes per hour.
- Photoperiod: 12 hours artificial fluorescent light/12 hours dark, music/light period.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- The test article (0.5 g) was applied moistened with tap- water.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 2 male and 1 females
- Details on study design:
- TEST SITE
- Area of exposure: approximately 24 hours before treatment, the dorsal fur was shaved with an electric clipper, exposing an area of approximately 100 square centimetres (10 cm x 10 cm).
- Type of wrap if used: on test day 1, the test article was applied to the intact skin of the shaved, area. It was covered with a 3.0 cm x 3.0 cm patch of surgical gauze. The gauze was covered with aluminium foil and then covered with an occlusive dressing. The dressing was wrapped around the abdomen and anchored with an elastic bandage.
REMOVAL OF TEST SUBSTANCE
- Washing: flushed with luk e warm tap water.
- Time after start of exposure: 4 hours after the application.
SCORING SYSTEM
The skin reaction was assessed according, to the QECD Guidelines for Testing of Chemicals, Section 4, number 404, pp. 3-4. The skin reaction was assessed at 1, 24, 48 and 72 hours intervals after the removal of the dressing, gauze patch and test article.
ERYTHEMA AND ESCHAR FORMATION
No erythema: 0
Very slight, erythema (barely perceptible): 1
Well defined erythemas_ 2
Moderate to severe erythema: 3
Severe erythema, (beet redness) to slight eschar formation (injuries irr depth): 4
Maximum possible score: 4
EDEMA FORMATION
No edema 0
Very slight, edema (barely perceptible): 1
Slight edema, (edges of area well defined by definite, raising): 2
Moderate edema (raised approximately 1 mm): 3
Severe edema (raised more than 1 mm and extending beyond area of exposure): 4
Maximum possible score: 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #55, #56, #57
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: #55, #56, #57
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- The test item showed a primary irritation score of 0 when applied to intact rabbit skin.
In the area, of application a black discoloration of the skin was observed which could be related to effects of the test article.
No destructions or irreversible alterations of the treated skin were observed. No corrosive effect was evident on the skin. - Other effects:
- TOXIC SYMPTOMS / MORTALITY
No acute toxic symptoms mere observed in the animals during the test period, and no mortality occurred.
BODY WEIGHTS
The body weight gain of all rabbits was similar.
NECROPSY
Due to the results obtained, no macroscopic organ examination was indicated.
Any other information on results incl. tables
Animal/sex | Reaction | 1 hr | 24 hrs | 48 hrs | 72 hrs | Mean 24, 48 and 72 hrs |
55 M | Erythema | 0 | 0 | 0 | 0 | 0.00 |
56 M | Erythema | 0 | 0 | 0 | 0 | 0.00 |
57 F | Erythema | 0 | 0 | 0 | 0 | 0.00 |
55 M | Oedema | 0 | 0 | 0 | 0 | 0.00 |
56 M | Oedema | 0 | 0 | 0 | 0 | 0.00 |
57 F | Oedema | 0 | 0 | 0 | 0 | 0.00 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified as skin irritatnt according to the CLP Regulation (EC) No. 1272/2008.
- Conclusions:
- not irritating
- Executive summary:
Method
The skin irritation/corrosion potential of the test item was assessed according to the OECD guideline 404 and EU Method B.4.
Results
Under the test conditions, the substance was found to cause a primary irritation score of 0 when applied to intact rabbit skin.
In the area of application, a black discoloration of the skin was observed which could be related to effects of the test article.
No corrosive effect had occurred on the skin at each measuring interval.
Conclusion
The mean values from gradings at 24, 48 and 72 hours after patch removal were lower than 2.3 in at least 2 of 3 animals for both erythema/eschar and oedema reactions.
In conclusion, the test item can be classified as non irritating, according to the CLP Regulation (EC 1272/2008).
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