Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-005-8 | CAS number: 102-09-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
- Principles of method if other than guideline:
- The animals were dosed intraperitoneally at 0.005, 0.01, 0.025, 0.05, 0.1, 0.25, 0.5 and 1 g/kg bw in DMSO. Animals were observed for 7 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Diphenyl carbonate
- EC Number:
- 203-005-8
- EC Name:
- Diphenyl carbonate
- Cas Number:
- 102-09-0
- Molecular formula:
- C13H10O3
- IUPAC Name:
- diphenyl carbonate
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- DMSO
- Doses:
- 0.005 g, 0.01 g, 0.025 g, 0.05 g, 0.1 g, 0.25 g, 0.5 g, 1 g/kg bw
- No. of animals per sex per dose:
- 10 animals per dose (presumably male)
- Details on study design:
- - Duration of observation period following administration: 7 days
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 200 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, the LD50 was determined to be 200 mg/kg.
- Executive summary:
The animals were dosed intraperitoneally at 0.005, 0.01, 0.025, 0.05, 0.1, 0.25, 0.5 and 1 g/kg bw in DMSO. Animals were observed for 7 days.
Under the conditions of this study, the LD50 was determined to be 200 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
