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Diss Factsheets
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EC number: 203-005-8 | CAS number: 102-09-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation))
- Principles of method if other than guideline:
- Directive EG L 133, part C
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Test organisms (species):
- activated sludge, domestic
- Details on inoculum:
- Concentration of the activated sludge was 320 mg/l
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Test temperature:
- 20 ± 2 °C
- pH:
- 6.8
- Dissolved oxygen:
- Oxygen consumption was recorded over a period of 6 minutes
- Nominal and measured concentrations:
- 1000, 1800, 3200, 5600, 10000 mg/L (nominal)
- Details on test conditions:
- The system was aerated and stirred during the test
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4 510 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- 60 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Conclusions:
- The 3h EC10 and the 3h EC50 of diphenyl carbonate to activated sludge is 60 mg/l and 4510 mg/l, respectively.
- Executive summary:
The principles of the method are those of Directive EG L 133, part C and correspond to the standardised guideline OECD 209. The study was conducted under GLP conditions.
During the study domestic activated sludge was exposed to the test material for 3 hours under static conditions at nominal concentrations of 1000, 1800, 3200, 5600 and 10 000 mg/L. The concentration of the activated sludge was 320 mg/L.
The EC50 was obtained with Probit Analysis whereby all concentrations were weighted equal. This study identifies the 3 h EC10 and the 3 h EC50 of diphenyl carbonate to activated sludge as 60 and 4510 mg/L, respectively.
Reference
The EC50 was obtained with Probit Analysis whereby all concentrations were weighted equal.
Description of key information
The toxicity of diphenyl carbonate to activated sludge was assessed using methodology comparable to OECD 209 (Bayer, 2000c). A 3 h EC10 of 60 mg/L and a 3 h EC50 of 4510 mg/L were determined.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 4 510 mg/L
- EC10 or NOEC for microorganisms:
- 60 mg/L
Additional information
This endpoint is addressed with one key study and one supporting study.
In the key study (Bayer, 2000c) the principles of the method are those of Directive EG L 133, part C and correspond to the standardised guideline OECD 209. The study was conducted under GLP conditions and was awarded a reliability score of 1 in accordance with the criteria for assessing data quality as set forth by Klimisch et al. (1997).
Domestic activated sludge was exposed to the test material for 3 hours under static conditions at nominal concentrations of 1000, 1800, 3200, 5600 and 10 000 mg/L. The concentration of the activated sludge was 320 mg/L
The EC50 was obtained with Probit Analysis whereby all concentrations were weighted equal. This study identifies the 3 h EC10 and the 3 h EC50 of diphenyl carbonate to activated sludge as 60 and 4510 mg/L, respectively.
The supporting study (Bayer, 1979) has been awarded a reliability score of 4 in accordance with the criteria for assessing data quality as set forth by Klimisch et al. (1997) as the documentation is insufficient for assessment. The study was not performed under GLP conditions, but follows the methodology of the cell multiplication inhibition test according to Bringmann and Kuehn (1977). The study identifies the EC0 to Pseudomonas putida (after a testing period of 16 hours) as > 280 mg/L.
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