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EC number: 202-409-1 | CAS number: 95-31-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute dermal and oral toxicity of the test substance TBBS is very low, indicated by LD50 values greater than 5000 mg/kg. The acute oral LD50 value in rats is greater than 6310 mg/kg (Monsanto Co. 1973) and the dermal LD50 value in rabbits is greater than 7940 mg/kg bw (Monsanto Co. 1973).
No acute inhalation study with TBBS is available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
- Principles of method if other than guideline:
- A 25% suspension of Santocure NS vulcanization accelerator (N-tert-butylbenzothiazole-2-sulphenamide) in corn oil was administrated by gavage to 4 groups of 5 (mixed males and females) Sprague-Dawley albino rats at doses of 6310 or 7940 mg/kg bw. A 10-day observation period followed administration.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 6310, 7940 mg/kg bw
- No. of animals per sex per dose:
- 5 per dose (mixed males and females)
- Control animals:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 6 310 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Clinical signs: reduced appetite and activity (three to five days in survivors), increased weakness, collapse, and death (in decedents).
- Mortality:
- 6310 mg/kg bw: 0/3 males, 0/2 females, combined: 0/5
7940 mg/kg bw: 1/2 males, 2/3 females, combined: 3/5
time of mortality: 4 to 9 days - Clinical signs:
- other: Reduced appetite and activity (three to five days in survivors), increased weakness, collapse, and death.
- Gross pathology:
- Decedents: Lung congestion, liver discoloration, acute gastrointestinal inflammation.
Surviors (10 days): Viscera appeared normal. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 > 6310 mg/kg bw (rats).
- Executive summary:
A 25% suspension of Santocure NS vulcanization accelerator (N-tert-butylbenzothiazole-2-sulphenamide) in corn oil was administrated by gavage to 4 groups of 5 (mixed males and females) Sprague-Dawley albino rats at doses of 6310 or 7940 mg/kg bw. A 10-day observation period followed administration. A LD50 > 6310 mg/kg bw (rats) was determined.
Reference
Mortality:
6310 mg/kg bw: 0/3 males, 0/2 females, combined: 0/5
7940 mg/kg bw: 1/2 males, 2/3 females, combined: 3/5
Time of mortality: 4 to 9 days
Clinical signs: reduced appetite and activity (three to five days in survivors), increased weakness, collapse, and death
Gross autopsy decedents: Lung congestion, liver discoloration, acute gastrointestinal inflammation
Surviors (10 days) viscera appeared normal
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 6 310 mg/kg bw
- Quality of whole database:
- Limited but acceptable documented study report which meets basic scientific principles.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
- Principles of method if other than guideline:
- A 40 % suspension of Santocure NS vulcanization accelerator (N-tert-butylbenzothiazole-2-sulphenamide) in corn oil was applied for 24 hours directly to the clipped, intact skin of 2 (1 male/1 female) New Zealand albino rabbits at a dose of 7940 mg/kg bw using semi-occlusive dressings.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Type of coverage:
- semiocclusive
- Vehicle:
- corn oil
- Duration of exposure:
- 24 h
- Doses:
- 7940 mg/kg bw
- No. of animals per sex per dose:
- 2 animals per dose
- Control animals:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 7 940 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Signs of intoxication: none
- Mortality:
- No mortalities occured.
- Clinical signs:
- other: None.
- Gross pathology:
- Viscera of animals appeared normal at sacrifice.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 > 7940 mg/kg bw (rabbit).
- Executive summary:
A 40 % suspension of Santocure NS vulcanization accelerator (N-tert-butylbenzothiazole-2-sulphenamide) in corn oil was applied for 24 hours directly to the clipped, intact skin of 2 (1 male/1 female) New Zealand albino rabbits at a dose of 7940 mg/kg bw using semi-occlusive dressings.
No mortalities occured. No obvious clinical signs were observed. Viscera of animals appeared normal at sacrifice. The dermal LD50 for Santocure NS vulcanization accelerator was greater than 7940 mg/kg bw.
Reference
Mortality: 0/1 male, 0/1 female, combined 0/2
Signs of intoxication: none
Survivors: 14 day, viscera appeared normal.
No mortalities occured. The dermal LD50 for Santocure NS vulcanization accelerator was greater than 7940 mg/kg bw. No obvious clinical signs were observed. Viscera of animals appeared normal at sacrifice.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 7 940 mg/kg bw
- Quality of whole database:
- Limited but acceptable documented study report which meets basic scientific principles.
Additional information
Acute toxicity: oral
The acute oral toxicity of TBBS was evaluated in an acute oral gavage study with Sprague-Dawley albino rats (Monsanto Co. 1973). A 25% suspension of the test substance in corn oil was administered by gavage to male and female rats at doses of 6310 or 7940 mg/kg bw. A 10-day observation period followed administration. The oral LD50 was greater than 6310 mg/kg bw. For the doses 6310 and 7940 mg/kg bw, the number of deaths were 0, and 3, respectively, out of 5 animals per group. Clinical signs were observed and included reduced appetite and activity (lasting 3 to 5 days in survivors), increasing weakness, collapse and death. Autopsy of decedents showed lung congestion, liver discoloration and acute gastrointestinal inflammation. Viscera of surviving animals appeared normal at sacrifice.
Acute toxicity: dermal
The acute dermal toxicity of the test substance TBBS was evaluated in acute dermal toxicity study with New Zealand albino rabbits (Monsanto Co. 1973). A 40 % suspension of the test substance in corn oil was applied for 24 hours directly to the clipped, intact skin of 2 (1 male and 1 female) New Zealand albino rabbits at a dose of 7940 mg/kg bw using semi-occlusive dressings. No mortality occurred. The dermal LD50 for the test substance TBBS was greater than 7940 mg/kg bw. No obvious clinical signs were observed. Viscera of animals appeared normal at sacrifice.
Justification for selection of acute toxicity – oral endpoint
The most reliable study is used
Justification for selection of acute toxicity – dermal endpoint
The most reliable study is used
Justification for classification or non-classification
The acute oral LD50 value in rats is greater than 6310 mg/kg (Monsanto Co. 1973) and the dermal LD50 value in rabbits is greater than 7940 mg/kg bw (Monsanto Co. 1973). No acute inhalation study is available.
According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is not justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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