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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-404-7 | CAS number: 106-50-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Several bacterial reverse mutation assays are available with the test substance, using several types and strains of bacteria. Based on a weight of evidence, the genotoxic potential was considered to be positive with metabolic activation in bacteria. In addition, the test substance was positive without metabolic activation in an in vitro chromosome aberration study, and positive with metabolic activation in an in vitro micronucleus test.
Therefore, an in vivo micronucleus study in accordance with OECD TG474 and an in vivo UDS test in accordance with OECD TG486 were performed. Based on the results of these studies, the test substance can be considered not genotoxic
Short description of key information:
In vivo micronucleus study (OECD TG474):
Under the conditions of the study, the test substance did not induce cytogenetic damage leading to micronucleus formation in the bone marrow of rats treated orally up to the maximal tolerated dose of 100 mg/kg, with clear demonstration that treated animals were exposed systemically. Therefore, the test substance was considered to be non-genotoxic in this micronucleus assay.
In vivo UDS test (OECD TG486):
Under the conditions of the study, there was no DNA damage leading to unscheduled DNA synthesis in hepatocytes obtained from rats treated orally with the test substance up to the Maximal Tolerated Dose of 100 mg/kg, with clear demonstration that animals were systemically exposed to the test item. Therefore, the test substance was considered to be non-genotoxic in the in vivo unscheduled DNA synthesis in rat hepatocytes.
Endpoint Conclusion: No adverse effect observed in vivo
(negative)
Justification for classification or non-classification
The test substance was genotoxic in vitro with or without metabolic activation. However, when tested in vivo no genotoxicity was observed. Therefore, the substance does not need to be classified for mutagenicity according the EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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