Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-822-1 | CAS number: 74-93-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Study period:
- First day of treatment: 13 April 2004. Experimental completion date: 16 June 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Reproduction/developmental toxicity screening test Method: other: OECD Guide-line 422
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- in vivo
Test material
- Reference substance name:
- Sodium methanethiolate
- EC Number:
- 225-969-9
- EC Name:
- Sodium methanethiolate
- Cas Number:
- 5188-07-8
- IUPAC Name:
- sodium methanethiolate
- Details on test material:
- Test substance: SODIUM METHYLMERCAPTIDE
Supplier: Arkema SA
Batch number : SMM33 0050-7
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals:
- Breeder: Charles River Laboratories France, L'Arbresle, France.
- Age/Weight: at the beginning of the treatment period, the males were 6 weeks old (body weight range: 183 g to 221 g), the females were 8 weeks old (body weight range: 183 g to 232 g).
- Acclimation: 7 days before the beginning of the treatment period.
Environmental conditions:
- temperature : 22 ± 2°C
- relative humidity : 50 ± 20%
- light/dark cycle : 12h/12h (7:00 - 19:00)
- ventilation : approximately 12 cycles/hour of filtered, non-recycled air.
Housing: Individually in suspended wire-mesh cages. Prior to delivery and during lactation, the animals were housed individually in polycarbonate cages.
Food and water:
- food: A04 C pelleted maintenance diet (SAFE, Villemoisson, Epinay-sur-Orge, France), ad libitum
- water: tap water (filtered with a 0.22 µm filter) ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- - Volume administered: 5 ml/kg
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- - Control of the stability: before the start of treatment
- Control of the concentrations: on weeks 1, 4 and 8 - Duration of treatment / exposure:
- - males:
. 28 days before mating, during the mating and post-mating periods until sacrifice (approximately 8 weeks in total),
- females:
. 28 days before mating,
. during the mating period,
. during pregnancy and lactation, until day 4 post-partum inclusive (between 8 to 9 weeks in total). - Frequency of treatment:
- once a day, 7 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5, 15, 45 mg/kg/day
Basis:
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent vehicle
- Statistics:
- - mean quantitative values compared by one-way analysis of variance and Dunnett test; proportions are compared by the Fisher exact probability test
- organ weight: test for normality of distribution, Bartlett test (homogeneity of variances between groups), Dunn test (not homogeneous) or Dunnett test
- *: p<0.05; **: p<0.01
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Remarks:
- reproductive performance and developmental toxicity
- Effect level:
- >= 45 mg/kg bw/day
- Sex:
- male/female
- Basis for effect level:
- other: No effect on reproductive performance and developmental toxicity
Any other information on results incl. tables
CHEMICAL ANALYSIS OF THE DOSAGE FORMS
- Stability: Satisfactory stability over a 9-day period at
+4°C.
- Concentration: satisfactory agreement between the nominal
and actual concentrations
CLINICAL EXAMINATION
- Mortality: there were no deaths in any group.
- Clinical signs:
. 45 mg/kg/d: hypotonia was transiently observed in all
males and females during the whole dosing period, ataxia was
observed at detailed clinical observations in 4 males and in
one female during week 5 or 6 of dosing, ptyalism was
observed in most males and females a few days after the
beginning of the study until the end of dosing.
. 5 and 15 mg/kg/d: no clinical sign was noted.
- Body-weight :
. 45 mg/kg/d: in the males, the group mean body weight gain
was statistically significantly lower during
the first week of dosing (days 1 to 8: 45 g vs. 55 g, -18%,
p<0.01) and remained marginally lower during the dosing
period. In the females, the group mean body weight gain was
marginally lower during the premating period and
significantly lower during the first week of pregnancy (day
0 to 7, 27 g vs. 42 g in controls, -36%, p<0.001).
. 5 and 15 mg/kg/d: no effect was noted.
- Food consumption:
. 45 mg/kg/d: in the males, the food consumption was
marginally lower during the whole study.
. 5 and 15 mg/kg/d: no effect was noted.
MATING AND FERTILITY DATA
- Mating index : no treatment-related effects.
- Pre-coital time : no treatment-related effects.
- Fertility index : 100% in all groups.
- Duration of gestation : no treatment-related effects.
- Gestation index (number of female with live
concepti/number of pregnant females) : 100% in all groups.
- Post-natal and neo-natal losses : no treatment-related
effects.
OBSERVATION OF THE PUPS AFTER BIRTH
- Mortality : no treatment-related effects.
- Clinical signs : no treatment-related effects.
- No gross external abnormalities were noted on day 5
post-partum before sacrifice.
- Pup body weight: no treatment-related effects.
- Sex ratio : no treatment-related effects.
PATHOLOGY
- Necropsy: no substance related effect at any dose-levels.
- Organ-weights: no substance related effect on the
reproductive organs.
- Microscopic examination: No treatment-related microscopic
abnormalities were noted in the testis, prostate, and
seminal vesicles, ovary and uterus.
Applicant's summary and conclusion
- Conclusions:
- The combined repeated dose toxicity and
reproductive/developmental toxicity of SODIUM
METHYLMERCAPTIDE, was evaluated, in male and female
Sprague-Dawley rats, after oral administration (gavage) of 5, 15 or 45 mg/kg/day, during an 8-week premating and mating periods until sacrifice for the males, or during a 4-week premating period, and through pregnancy and lactation, until day 4 post-partum, for the females.
There were no substance-induced effects on the parental male or female reproductive performance, or on the progeny at any dose-level.
The No Observed Effect Level (NOEL) for reproductive performance and developmental toxicity is established at 45 mg/kg/day. - Executive summary:
In a combined repeated-dose/reproductive/developmental toxicity screening study (OECD TG 422), Sprague-Dawley rats (10/sex/dose) were administered 0, 5, 15 or 45 mg/kg bw/day of sodium methanethiolate in water by gavage daily at a volume of 5 ml/kg during an 8-week premating and mating periods until sacrifice for the males, or during a 4-week premating period, and through pregnancy and lactation, until day 4 post-partum, for the females. Females were paired with males from the same dose-level group until mating occurred or 2 weeks had elapsed. Gestation was monitored. Females were allowed to deliver normally and to rear their progeny until day 5 post-partum. During the lactation period, the pups were examined daily for survival and clinical signs and body weights were recorded on days 1 and 4 postpartum. At final sacrifice of the parents, specified organs were weighed and a complete macroscopic post-mortem examination was performed.
No substance-related effects were noted on the male and female reproductive performance and no indication of substance-induced developmental toxicity were observed at any dose levels.
The No Observed Effect Level (NOEL) for reproductive performance and developmental toxicity is established at 45
mg/kg/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.