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Diss Factsheets
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EC number: 200-822-1 | CAS number: 74-93-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2b: study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sodium methanethiolate
- EC Number:
- 225-969-9
- EC Name:
- Sodium methanethiolate
- Cas Number:
- 5188-07-8
- IUPAC Name:
- sodium methanethiolate
- Details on test material:
- Test substance: 32.9% solution in water
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not relevant
Sampling and analysis
- Analytical monitoring:
- yes
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Batch n° 03/Br/04/1 was supplied by Aquatrade International BV. Fish were placed under the test conditions 150 days before beginning of the test. Fish selected for the test were all from the same batch and were of the same age with a size ranging from 3.3 to 3.6 cm.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Test temperature:
- 22.5 +/- 1ºC
- pH:
- From 6.63 to 6.95 whatever the concentration considered
- Dissolved oxygen:
- From 80 to 236% whatever the concentration considered
- Nominal and measured concentrations:
- nominal concentrations of 0.95, 1.7, 3.1, 5.6, or 10 mg active ingredient (a.i.)/L
- Details on test conditions:
- - closed test vessels
- programmed lighting which provided a controlled lighting cycle (12 hours light/12 hours dark)
- renewal of the solutions every 24 hours.
- Two replicate test chambers were maintained for each treatment and control group, with 5 fish per chamber, for a total of 10 fish per test concentration.
Sodium mercaptide being unstable at neutral pH, test was carried out in closed reactors.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 0.53 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.8 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- At test initiation and termination, the test solutions were observed to be clear and no precipitate was recorded. The following mean measured concentration values were used to calculate the median lethal doses.
Despite the renewal of test medium every 24 hours, the concentration of sodium methanethiolate decreased by over 20% in the aged solutions. The exposure concentration was therefore considered to be equivalent to the mean measured concentration of the initial fresh (excluding the 0 hour sample) and the same concentration 'aged' for 24 hours and this exposure concentration was used to calculate the median lethal concentrations.
The examination of the fish did not reveal any abnormal behavior over the course of the study. At the higher concentrations of test substance, the fish showed red gills and low mobility.
Based on the mean measured test concentrations and the mortality results, the median lethal concentrations were determined to be as follows: Results LC50-24h = 2.9 LC50-48h = 2.9 LC50-72h = 2.0 LC50-96h = 1.8 - Results with reference substance (positive control):
- The sensitivity of fish is tested at least once for each new batch of fish. For reference, the results of the last test carried out on November 13, 2003 gave a LC50-24h of 230 mg/L.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- Except the concentrations which were not maintained constant during the exposure phase. Concentration in the air phase was not measured.
- Conclusions:
- 96-Hour LC50: 1.8 mg sodium methanethiolate (a.i.)/L
95% Confidence Limits: Not determined
No-Mortality Concentration: 0.53 mg sodium methanethiolate (a.i.)/L
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