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EC number: 421-820-9 | CAS number: 192268-65-8 CD 28-0132; IRGALUBE 232
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- 92/69/EEC
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- A mixture of: triphenylthiophosphate and tertiary butylated phenyl derivatives
- EC Number:
- 421-820-9
- EC Name:
- A mixture of: triphenylthiophosphate and tertiary butylated phenyl derivatives
- Cas Number:
- 192268-65-8
- Molecular formula:
- Unspecified
- IUPAC Name:
- O,O,O-triphenyl phosphorothioate; O-2,4-di-tert-butylphenyl O,O-diphenyl phosphorothioate; O-2-tert-butylphenyl O,O-diphenyl phosphorothioate; O-2-tert-butylphenyl O-4-tert-butylphenyl O-phenyl phosphorothioate; O-4-tert-butylphenyl O,O-diphenyl phosphorothioate
- Details on test material:
- - Appearance: yellowish liquid.
- Storage condition of test material: Room temperature in dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Froxfield (U.K.) Ltd., Petersfield, Hampshire, England.
- Age at study initiation: Approximately 11 to 13 weeks of age.
- Weight at study initiation: 2.6 to 3.1 kg.
- Housing: housed individually in metal cages with perforated floors.
- Diet: ad libitum; standard laboratory diet SDS Stanrab (P) Rabbit Diet (not analysed for nutrients, contaminants or micro-organisms)
- Wate: ad libitum; (routinely analysed for contamination, usually weekly).
- Acclimation period: All rabbits were acclimatised to the experimental environment.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19°C.
- Humidity (%): 30 – 70%.
- Air changes (per hr): 19 air changes per hour.
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL: 0.5 mL
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 4 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Site of application: Dorso-lumbar region.
- Area of exposure: applied under a 25 mm x 25 mm gauze pad to intact skin on each animal.
- Type of wrap if used: Each treatment site was covered with "Elastoplast" elastic adhesive dressing.
REMOVAL OF TEST SUBSTANCE
- Washing: Yes; with warm water (30° to 40°C). The treated area was blotted dry with absorbent paper
- Time after start of exposure: 4 hours.
Clinical signs:
All animals were observed daily for signs of ill health or toxicity.
Dermal responses:
Examination of the treated skin was made on Day 1 (i.e., approximately 60 minutes after removal of the dressings) and on Days 2, 3 and 4 (equivalent to 24, 48 and 72 hours after exposure).
SCORING SYSTEM:
Local dermal irritation was assessed using the prescribed numerical system:
Erythema and eschar formation:
No erythema 0
Very slight erythema (barely perceptible) 1
Well-defined erythema 2
Moderate to severe erythema 3
Severe erythema (beet redness) to slight eschar formation (injuries in depth) preventing erythema reading 4
Oedema formation:
No oedema 0
Very slight oedema (barely perceptible) 1
Slight oedema (edges of area well-defined by definite raising) 2
Moderate oedema (raised approximately 1 millimetre) 3
Severe oedema (raised more than 1 millimetre and extending beyond the area of exposure) 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.333
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 h after exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.667
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h after exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.667
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h after exposure
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.333
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 h after exposure
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.667
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h after exposure
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.667
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h after exposure
- Irritant / corrosive response data:
- Erythema score: Max. duration: 72 h; Max. value at end of observation period: 0 (related to all animals).
Edema score: Max. duration: 48 h; Max. value at end of observation period: 0 (related to all animals).
Reversibility of any observed effect: Changes fully reversible within 4 days. - Other effects:
- There were no signs of toxicity or ill health in any rabbit during the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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