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EC number: 421-820-9 | CAS number: 192268-65-8 CD 28-0132; IRGALUBE 232
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance caused transient irritation of the rabbit skin. Very slight to well-defined erythema was observed. Erythema was fully reversible in all animals within 72 hours following termination of exposure. Very slight oedema demonstrated by all animals was fully reversible within 48 hours after the end of exposure. The test item also caused mild conjunctival reactions in 3/3 animals. The effects on the conjunctivae were fully reversible in all animals within 48 hours after instillation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation
In a primary dermal irritation study performed pursuant to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion 92/69/EEC), 0.5 mL of the test article was applied on gauze pads and placed semi-occlusively to the shaved skin of 3 New Zealand White rabbits. Exposure was performed for the duration of 4 hours. At the end of exposure, exposure sites were washed with water. Animals were observed until total reversal of symptoms. Skin changes were scored using the OECD Draize method. Mean Draize scores after 24, 48 and 72 hours were calculated per animal for erythema and oedema and used for assessment of irritation potential. Mean Draize scores after 24, 48 and 72 hours, calculated for animals 1/2/3 were 0.333/1.667/0.667 for erythema and 0.333/0.667/0.667 for oedema. There were no signs of systemic toxicity or ill health in any rabbit during the observation period (Huntingdon Life Sciences Ltd. 1995). This study is reliable and considered suitable for assessment of skin irritation.
Eye Irritation
The eye irritation potential of the test substance was determined according to the EU Method B.5 (Acute Toxicity to Eye Irritation / Corrosion). 0.1 mL of the test article was instilled to the conjunctival sac of one eye of each of 3 New Zealand White rabbits. The other eye was not treated. Eyes were not washed after instillation. After instillation, the examination of the eyes was made after 1 hour and 1, 2, 3 (equivalent to 24, 48 and 72 hours after instillation), 4 and 7 days afterwards. Scoring was performed using the OECD Draize scoring method. Mean draize scores after 24, 48 and 72 hours were calculated per animal for corneal opacity, iritis, conjunctivae redness and chemosis and used for the assessment of irritation potential. The mean values of the draize scores taken for animal 1/2/3 after 24, 48 and 72 hours were: 0/0/0 for the opacity of the cornea, 0/0/0 for effects on the iris, 0/0.333/0 for redness, and 0/0/0 for chemosis of the conjunctiva (Huntingdon Life Sciences Ltd. 1995). This study is reliable and suitable for assessment of eye irritation.
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for the purpose of classification under Regulation 1272/2008. Based on the criteria laid down in Regulation (EC) No.1272/2008 classification for skin and eye irritation is not warranted.
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