Registration Dossier
Registration Dossier
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EC number: 232-234-6 | CAS number: 7790-94-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicological Evaluations 14
- Author:
- BG Chemie
- Year:
- 1 995
- Bibliographic source:
- Potential Health Hazards of Existing Chemicals
- Reference Type:
- publication
- Title:
- Zur Bewertung der akuten Toxizität einer leichthydrolysierbaren Verbindung-der Chlorsulfonsäure.
- Author:
- Mamleva NK, and Bakhtizina GZ
- Year:
- 1 976
- Bibliographic source:
- Tr. Mosk. NII Gigieny 9, 110-113.
Materials and methods
- Principles of method if other than guideline:
- A single dose of chlorosulphuric acid was applied into the conjunctival sac of the eye of the rabbit.
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study.
Test material
- Reference substance name:
- Chlorosulphuric acid
- EC Number:
- 232-234-6
- EC Name:
- Chlorosulphuric acid
- Cas Number:
- 7790-94-5
- Molecular formula:
- ClHO3S
- IUPAC Name:
- sulfurochloridic acid
- Details on test material:
- - Name of test material (as cited in study report): chlorosulphuric acid.
- Analytical purity: no data.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
Results and discussion
In vivo
- Irritant / corrosive response data:
- One month after the instillation of a single dose of chlorosulphuric acid into the conjuctival sac of the eye of the rabbit, „leukoma of the cornea“ (milky clouding of the cornea) and enophthalmia occurred, with complete loss of transparency of the optical media.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
