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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Toxicological Evaluations 14
Author:
BG Chemie
Year:
1995
Bibliographic source:
Potential Health Hazards of Existing Chemicals
Reference Type:
publication
Title:
Zur Bewertung der akuten Toxizität einer leichthydrolysierbaren Verbindung-der Chlorsulfonsäure.
Author:
Mamleva NK, and Bakhtizina GZ
Year:
1976
Bibliographic source:
Tr. Mosk. NII Gigieny 9, 110-113.

Materials and methods

Principles of method if other than guideline:
Single application of chlorosulphuric acid to the skin of rabbits.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Chlorosulphuric acid
EC Number:
232-234-6
EC Name:
Chlorosulphuric acid
Cas Number:
7790-94-5
Molecular formula:
ClHO3S
IUPAC Name:
sulfurochloridic acid
Details on test material:
- Name of test material (as cited in study report): chlorosulfonic acid.
- Analytical purity: not reported.

Test animals

Species:
rabbit

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Amount / concentration applied:
no data.

Results and discussion

In vivo

Irritant / corrosive response data:
A single application of chlorosulphuric acid to the skin of rabbits caused a "deep ulcer", that healed slowly with the formation of pronounced scars.
Other effects:
No further details.

Applicant's summary and conclusion