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EC number: 275-965-6 | CAS number: 71735-74-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: "Hazardous Substances Regulations" under the U.S. Federal Hazardous Substances Labelling Act Sect. 191.11 (February 1955).
- Principles of method if other than guideline:
- Two test sites lateral to the mid line of the back were used on each rabbit. Immediately before the application of the test compound, the right hand site was abraded. Assessments of skin reactions were made after 24 hrs and 72 hrs and for any further period considered necessary up to 14 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethyl 3-[[bis(1-methylethoxy)phosphinothioyl]thio]propionate
- EC Number:
- 275-965-6
- EC Name:
- Ethyl 3-[[bis(1-methylethoxy)phosphinothioyl]thio]propionate
- Cas Number:
- 71735-74-5
- Molecular formula:
- C11H23O4PS2
- IUPAC Name:
- ethyl 3-{[bis(propan-2-yloxy)(sulfanylidene)-λ⁵-phosphanyl]sulfanyl}propanoate
- Details on test material:
- - Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 12-14 weeks
- Weight at study initiation: 2.32 kg (males) and 2.57 kg (females)
- Housing: caged individually
- Diet: A commercial irradiated diet (Styles-Oxoid) ad libitum
- Water: Sterile filtered waterad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 1
- Humidity (%): 50-70
- Photoperiod (hrs dark / hrs light): 14 / 10
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL - Duration of treatment / exposure:
- 24 h
- Observation period:
- 14 d
- Number of animals:
- 6 (3 male and 3 female)
- Details on study design:
- TEST SITE
- Area of exposure: The backs of the rabbits, shaved over an area of at least 10% of the total body surface. Two test sites lateral to the mid line of
the back were used on each rabbit. Immediately before the application of the test compound, the right hand site was abraded with the point of a sterile hypodermic needle. The left hand sit's remained intact.
- % coverage: 2.5 cm2
- Type of wrap if used: gauze covered with aluminum foil secured with "Sleek" adhesive tape (Smith and Nephew, Hull, England). The test sites were then covered by a 6" wide "Coban" self adhesive bandage (3M Company, Wigmore Street, London)
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24 h
SCORING SYSTEM: Draize et al. (1944) J. Pharmac. Exp. Ther. 82:377
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- intact skin
- Time point:
- 72 h
- Score:
- 1.42
- Max. score:
- 8
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- intact skin
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- intact skin
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within:
- Remarks:
- 72 h
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- intact skin
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- intact skin
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
Erythema formation
No/ Sex | Intact | Abraded | total | ||
24 h | 72 h | 24 h | 72 h | ||
11/male | 1 | 0 | 1 | 0 | |
13 | 1 | 0 | 1 | 0 | |
15 | 2 | 0 | 2 | 0 | |
12/female | 1 | 0 | 1 | 0 | |
14 | 2 | 0 | 2 | 0 | |
16 | 1 | 0 | 1 | 0 | |
Mean | 1.33 | 0.00 | 1.33 | 0.00 | 2.67 |
Oedema formation
No/ Sex | Intact | Abraded | total | ||
24 h | 72 h | 24 h | 72 h | ||
11/male | 1 | 0 | 1 | 0 | |
13 | 1 | 0 | 2 | 0 | |
15 | 2 | 0 | 1 | 0 | |
12/female | 2 | 0 | 1 | 0 | |
14 | 2 | 0 | 2 | 0 | |
16 | 1 | 0 | 2 | 0 | |
Mean | 1.50 | 0.00 | 1.50 | 0.00 | 3.00 |
Erythema + Oedema = 5.67
Primary Irritation Score = 1.42
Mean erythema score of 24 and 72 hour readings, mean of all animals = 0.67
Mean edema score of 24 and 72 hour readings, mean of all animals = 0.75
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Treatment with the test substance resulted in minimal erythema and edema formations, reversible within 72h. Therefore, the substance is considered to be not irritating.
- Executive summary:
In a pre-GLP study performed to assess the primary irritation potential of the test substance, six New Zealand White rabbits (three males and three females) were treated dermally with the test compound. Twenty-four hours prior to treatment, the the backs of the rabbits were shaved over an area consisting of at least 10% of the total body surface. Two test sites lateral to the mid line of the back were used on each rabbit. Immediately before the application of the test compound, the right hand site was abraded with the point of a sterile hypodermic needle. The left hand sites remained intact. 0.5 ml of the test compound was applied to each test site on a 2.5 cm2 gauze patch and covered occlusively. After 24 hours the dressing was removed and the intact and abraded application sites were assessed for oedema and erythema, a further assessment was made after 72 hours and for any further period considered necessary up to 14 days. Only minimal irritation was observed, the mean values for erythema and edema after 24 and 72 hour timepoints (all animals) were 0.67 and 0.75, respecitvely. All effects were fully reversible within 72 hours.Based on this result, the test substance is considered not irritating to the skin and does not require classification.
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